Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.31 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.31 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.31 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.31 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.31 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.31 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.31 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydantoin SCHEMBL27558390 | 0.77 | CRBN (0.33) | — | |
| SCHEMBL27801700 | 0.77 | TNKS2 (0.49) | TSHR | |
| SCHEMBL28041715 | 0.73 | — | — | |
| SCHEMBL27458092 | 0.71 | CREBBP (0.38) | TSHR | |
| SCHEMBL28042886 | 0.58 | — | — | |
| Sulfuric Acid SCHEMBL27435856 | 0.57 | — | — | |
| Sulfuric Acid SCHEMBL27892078 | 0.57 | CA5A (0.86) | TSHRTDP1LMNACYP3A4 | |
| Sulfuric Acid SCHEMBL32912 | 0.57 | — | — | |
| Sulfuric Acid SCHEMBL9953249 | 0.57 | CA5A (0.86) | TSHRTDP1LMNACYP3A4 | |
| SCHEMBL8439659 | 0.55 | TSHR (0.50) | TSHRTDP1LMNACYP3A4GABRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1384825-A | Benzylidene-thiazolidinediones and analogues thereof and their use in the treatment of diabetes | MAXIA PHARMACEUTICALS INC (US) | 2002-12-11 | — | — | CN | claimed |
| CN-1774246-A | Substituted isochroman compounds for the treatment of metabolic disorders, cancer and other diseases | INCYTE SAN DIEGO INC (US) | 2006-05-17 | — | — | CN | disclosed |
| CN-1384825-A | Benzylidene-thiazolidinediones and analogues thereof and their use in the treatment of diabetes | MAXIA PHARMACEUTICALS INC (US) | 2002-12-11 | — | — | CN | disclosed |