Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | IDO1 | P14902 | 3/20 | 0.43 |
| ▸ | TDO2 | P48775 | 3/20 | 0.43 |
| ▸ | FBP1 | P09467 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | APP | P05067 | 1/20 | 0.41 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.41 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.40 |
| ▸ | PGR | P06401 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27576872 | 0.81 | RAPGEF4 (0.53) | RAPGEF4IDO1TDO2MEN1KMT2A | |
| SCHEMBL27576616 | 0.73 | RAPGEF4 (0.37) | RAPGEF4APPSMN1; SMN2MAPT | |
| SCHEMBL27582167 | 0.72 | TNF (0.39) | MEN1KMT2ASMN1; SMN2RAB9ALMNA | |
| SCHEMBL27561357 | 0.72 | TDP1 (0.34) | ALDH1A1MAPT | |
| SCHEMBL28844772 | 0.72 | IDO1 (0.57) | RAPGEF4IDO1TDO2MEN1KMT2A | |
| SCHEMBL29865062 | 0.72 | IDO1 (0.57) | RAPGEF4IDO1TDO2MEN1KMT2A | |
| SCHEMBL29865339 | 0.71 | IDO1 (0.61) | RAPGEF4IDO1TDO2MEN1KMT2A | |
| SCHEMBL28844660 | 0.71 | IDO1 (0.61) | RAPGEF4IDO1TDO2MEN1KMT2A | |
| SCHEMBL27581860 | 0.71 | EGFR (0.45) | RAPGEF4IDO1FBP1 | |
| SCHEMBL30597995 | 0.68 | TSHR (0.57) | RAPGEF4TSHRIDO1TDO2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1351498-A | Pyrrolotriazines inhibitors of kinases | BRISTOL MYERS SQUIBB CO (US) | 2002-05-29 | — | — | CN | claimed |
| CN-1351498-A | Pyrrolotriazines inhibitors of kinases | BRISTOL MYERS SQUIBB CO (US) | 2002-05-29 | — | — | CN | disclosed |