Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNF | P01375 | 1/20 | 0.39 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | KCNQ3 | O43525 | 6/20 | 0.34 |
| ▸ | KCNQ2 | O43526 | 6/20 | 0.34 |
| ▸ | KCNQ1 | P51787 | 3/20 | 0.34 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.34 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.34 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.34 |
| ▸ | CDK1 | P06493 | 1/20 | 0.34 |
| ▸ | CDK4 | P11802 | 1/20 | 0.34 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.34 |
| ▸ | CCND1 | P24385 | 1/20 | 0.34 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | CDK7 | P50613 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27576616 | 0.74 | RAPGEF4 (0.37) | GAAMAPTSMN1; SMN2 | |
| SCHEMBL27561378 | 0.72 | RAPGEF4 (0.46) | MEN1ALDH1A1LMNAKMT2AMAPT | |
| SCHEMBL27498048 | 0.68 | GRM4 (0.46) | TNFGRM4PIK3CAALDH1A1KCNQ3 | |
| SCHEMBL27561357 | 0.68 | TDP1 (0.34) | ALDH1A1KDM4EGAAMAPTL3MBTL1 | |
| Hydrochloric Acid SCHEMBL27496401 | 0.67 | GRM4 (0.44) | TNFGRM4PIK3CAALDH1A1KCNQ3 | |
| SCHEMBL4442545 | 0.67 | ADRA2A (0.49) | TNFMEN1ALDH1A1LMNAKMT2A | |
| SCHEMBL27581860 | 0.66 | EGFR (0.45) | GAA | |
| SCHEMBL26955849 | 0.65 | TNF (0.45) | TNFGRM4PIK3CAKCNQ3KCNQ2 | |
| SCHEMBL30824397 | 0.65 | TNF (0.45) | TNFGRM4PIK3CAKCNQ3KCNQ2 | |
| SCHEMBL16881725 | 0.65 | GRM4 (0.42) | TNFGRM4PIK3CAKCNQ3KCNQ2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1351498-A | Pyrrolotriazines inhibitors of kinases | BRISTOL MYERS SQUIBB CO (US) | 2002-05-29 | — | — | CN | claimed |