Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.53 |
| ▸ | APP | P05067 | 1/20 | 0.47 |
| ▸ | IDO1 | P14902 | 5/20 | 0.46 |
| ▸ | TDO2 | P48775 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.43 |
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27564357 | 0.81 | ALDH3A1 (0.46) | RAPGEF4MEN1KMT2ALMNASMN1; SMN2 | |
| SCHEMBL27561378 | 0.81 | RAPGEF4 (0.46) | RAPGEF4APPIDO1TDO2MEN1 | |
| SCHEMBL29865339 | 0.77 | IDO1 (0.61) | RAPGEF4APPIDO1TDO2MEN1 | |
| SCHEMBL28844660 | 0.77 | IDO1 (0.61) | RAPGEF4APPIDO1TDO2MEN1 | |
| SCHEMBL29865062 | 0.76 | IDO1 (0.57) | RAPGEF4IDO1TDO2MEN1HTT | |
| SCHEMBL28844772 | 0.76 | IDO1 (0.57) | RAPGEF4IDO1TDO2MEN1HTT | |
| SCHEMBL27564358 | 0.75 | PTGS1 (0.43) | MEN1HTTKMT2ALMNASMN1; SMN2 | |
| SCHEMBL27561517 | 0.75 | RAPGEF4 (0.33) | RAPGEF4MEN1KMT2ASOS1 | |
| SCHEMBL27888200 | 0.73 | ARNT (0.48) | MEN1HTTKMT2ALMNAMAPT | |
| SCHEMBL27582103 | 0.71 | KDR (0.40) | MEN1KMT2ANPC1RAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1351498-A | Pyrrolotriazines inhibitors of kinases | BRISTOL MYERS SQUIBB CO (US) | 2002-05-29 | — | — | CN | claimed |
| CN-1351498-B | Pyrrolotriazines inhibitors of kinases | BRISTOL MYERS SQUIBB CO | 2012-08-15 | — | — | CN | disclosed |
| CN-1351498-A | Pyrrolotriazines inhibitors of kinases | BRISTOL MYERS SQUIBB CO (US) | 2002-05-29 | — | — | CN | disclosed |