Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | TYR | P14679 | 1/20 | 0.45 |
| ▸ | DOHH | Q9BU89 | 1/20 | 0.45 |
| ▸ | GRIA1 | P42261 | 7/20 | 0.44 |
| ▸ | GRIA2 | P42262 | 7/20 | 0.44 |
| ▸ | GRIA4 | P48058 | 7/20 | 0.44 |
| ▸ | GRIK5 | Q16478 | 5/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.43 |
| ▸ | SLC7A11 | Q9UPY5 | 2/20 | 0.43 |
| ▸ | BLM | P54132 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | GRM5 | P41594 | 1/20 | 0.43 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.43 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10077574 | 0.80 | GRM5 (0.46) | GRIA1GRIA2GRIA4GRIK5CYP1A2 | |
| SCHEMBL8481264 | 0.78 | PTGS1 (0.42) | CYP1A2BLMALDH1A1MAPK1CYP2C19 | |
| SCHEMBL17254420 | 0.77 | MGLL (0.38) | CYP1A2BLMALDH1A1MAPK1CYP2C19 | |
| SCHEMBL14679245 | 0.76 | MGLL (0.55) | ALDH1A1MAPK1PTGS1PTGS2PKM | |
| SCHEMBL22687997 | 0.76 | MGLL (0.55) | ALDH1A1MAPK1PTGS1PTGS2PKM | |
| N-Ethylmaleimide SCHEMBL22397763 | 0.76 | PTGS1 (0.55) | GRIA1GRIA2GRIA4CYP1A2SLC7A11 | |
| SCHEMBL7165635 | 0.75 | APAF1 (0.43) | CYP1A2BLMALDH1A1CYP2C19HIF1A | |
| Hydrochloric Acid SCHEMBL22657871 | 0.74 | MGLL (0.53) | BLMALDH1A1MAPK1PTGS1PTGS2 | |
| Hydrochloric Acid SCHEMBL22657875 | 0.74 | MGLL (0.53) | BLMALDH1A1MAPK1PTGS1PTGS2 | |
| Hydrochloric Acid SCHEMBL28705925 | 0.74 | MGLL (0.53) | BLMALDH1A1MAPK1PTGS1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105612172-A | Cyclic polypeptides for the treatment of heart failure | NOVARTIS AG | 2016-05-25 | — | — | CN | disclosed |
| CN-101980725-B | Prodrug comprising a drug linker conjugate | ASCENDIS PHARMA AS | 2013-06-12 | — | — | CN | disclosed |
| CN-101980725-A | Prodrug comprising a drug linker conjugate | ASCENDIS PHARMA AS | 2011-02-23 | — | — | CN | disclosed |
| CN-1246323-C | Nitrogen-based camptothecin derivatives | CALIFORNIA PACIFIC MED CENTER (US) | 2006-03-22 | — | — | CN | disclosed |
| CN-1555385-A | Ligands to enhance cellular uptake of biomolecules | �����ɷ� | 2004-12-15 | — | — | CN | disclosed |
| CN-1454097-A | Polymer-modified synthetic proteins | GRYPHON SCIENCES (US) | 2003-11-05 | — | — | CN | disclosed |