Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 3/20 | 0.55 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.55 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | CTPS1 | P17812 | 6/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27538737 | 0.91 | KMT2A (0.46) | HSD11B1HSD17B1HSD17B2KMT2AMEN1 | |
| SCHEMBL27534026 | 0.89 | CTPS1 (0.47) | HSD11B1HSD17B1HSD17B2KMT2AMEN1 | |
| SCHEMBL28755208 | 0.85 | HSD11B1 (0.38) | HSD11B1HSD17B1HSD17B2KMT2AMEN1 | |
| SCHEMBL27622706 | 0.83 | KMT2A (0.37) | HSD11B1HSD17B1HSD17B2KMT2AMEN1 | |
| SCHEMBL3616862 | 0.82 | HSD11B1 (0.66) | HSD11B1HSD17B1HSD17B2KMT2AMEN1 | |
| SCHEMBL3621399 | 0.78 | HSD11B1 (0.64) | HSD11B1HSD17B1HSD17B2KMT2AMEN1 | |
| SCHEMBL27534005 | 0.76 | KMT2A (0.38) | HSD11B1HSD17B1HSD17B2KMT2AMEN1 | |
| SCHEMBL27622959 | 0.76 | NPC1 (0.35) | HSD11B1HSD17B1HSD17B2KMT2AMEN1 | |
| SCHEMBL27512877 | 0.75 | KMT2A (0.67) | KMT2AMEN1POLBALDH1A1CYP2C9 | |
| SCHEMBL27534122 | 0.74 | KMT2A (0.56) | KMT2AMEN1POLBALDH1A1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1249039-C | Inhibitors of 11 beta-hydroxysteroid dehydrogenase type I | BIOVITRUM AB (SE) | 2006-04-05 | — | — | CN | claimed |
| CN-1438997-A | Inhibitors of 11-beta-hydroxy steroid dehydrogenase type I | BIOVITRUM AB (SE) | 2003-08-27 | — | — | CN | claimed |
| CN-1249039-C | Inhibitors of 11 beta-hydroxysteroid dehydrogenase type I | BIOVITRUM AB (SE) | 2006-04-05 | — | — | CN | disclosed |
| CN-1438997-A | Inhibitors of 11-beta-hydroxy steroid dehydrogenase type I | BIOVITRUM AB (SE) | 2003-08-27 | — | — | CN | disclosed |