Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APLNR | P35414 | 1/20 | 0.38 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.32 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.31 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.31 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.31 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.31 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.31 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.31 |
| ▸ | CES2 | O00748 | 1/20 | 0.31 |
| ▸ | CES1 | P23141 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9072518 | 0.84 | APLNR (0.39) | APLNRGPR139PKMPSEN1PSEN2 | |
| SCHEMBL27899325 | 0.83 | PSEN1 (0.34) | APLNRPKMP2RX7PSEN1PSEN2 | |
| SCHEMBL1345761 | 0.81 | PDE2A (0.43) | APLNRGPR139 | |
| SCHEMBL6858040 | 0.81 | APLNR (0.43) | APLNRGPR139PKMCES2CES1 | |
| SCHEMBL2478679 | 0.81 | APLNR (0.43) | APLNRGPR139PKMCES2CES1 | |
| SCHEMBL17766971 | 0.81 | PDE2A (0.43) | APLNRGPR139 | |
| SCHEMBL7081498 | 0.81 | PDE2A (0.43) | APLNRGPR139 | |
| SCHEMBL3708094 | 0.81 | APLNR (0.43) | APLNRGPR139PKMCES2CES1 | |
| SCHEMBL30848143 | 0.81 | APLNR (0.43) | APLNRGPR139PKMCES2CES1 | |
| SCHEMBL29453752 | 0.80 | CES2 (0.43) | APLNRPSEN1PSEN2APH1BNCSTN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101679395-B | Triazolyl aminopyrimidine compounds | LILLY CO ELI | 2012-06-13 | — | — | CN | disclosed |
| CN-101679395-A | triazolyl aminopyrimidine compounds | LILLY CO ELI | 2010-03-24 | — | — | CN | disclosed |
| CN-101501005-A | Arylaminoaryl-alkyl-substituted imidazolidine-2, 4-diones, processes for their preparation, medicaments comprising these compounds and their use | SANOFI AVENTIS (FR) | 2009-08-05 | — | — | CN | disclosed |
| CN-1319963-C | Dihydrothiaphenanthrenecarbonylguanidines: composition, process of making, and use as medicament or diagnostic aid | AVENTIS PHARMACEUTICAL GERMANY (DE) | 2007-06-06 | — | — | CN | disclosed |
| CN-1630649-A | Dihydrothiaphenanthrenecarbonylguanidines: composition, process of making, and use as medicament or diagnostic aid | AVENTIS PHARMACEUTICAL GERMANY (DE) | 2005-06-22 | — | — | CN | disclosed |