Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | ERN1 | O75460 | 4/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | SRC | P12931 | 1/20 | 0.36 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | CA12 | O43570 | 2/20 | 0.33 |
| ▸ | CA1 | P00915 | 2/20 | 0.33 |
| ▸ | CA9 | Q16790 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL278950 | 0.88 | ERN1 (0.42) | TDP1ERN1PTPN1ALDH1A1HPGD | |
| SCHEMBL19810818 | 0.83 | ALDH1A1 (0.49) | ERN1ALDH1A1CA12CA1CA9 | |
| SCHEMBL14679006 | 0.83 | ERN1 (0.40) | ERN1PTPN1ALDH1A1HPGDCA12 | |
| SCHEMBL17786204 | 0.83 | ALDH1A1 (0.40) | ERN1ALDH1A1HPGDSRCSMN1; SMN2 | |
| SCHEMBL6902425 | 0.81 | PTPN1 (0.38) | ERN1PTPN1ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL275754 | 0.81 | ERN1 (0.39) | TDP1ERN1ALDH1A1CA12CA1 | |
| SCHEMBL2458060 | 0.81 | KMT2A (0.33) | TDP1ALDH1A1CA12CA1CA9 | |
| SCHEMBL6093144 | 0.78 | TDP1 (0.55) | TDP1ERN1PTPN1ALDH1A1HPGD | |
| SCHEMBL29722800 | 0.77 | ALDH1A1 (0.48) | TDP1ERN1ALDH1A1HPGDSRC | |
| SCHEMBL1201100 | 0.77 | ALDH1A1 (0.48) | TDP1ERN1ALDH1A1HPGDSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107001309-B | Bis (sulfonamide) derivatives and their use as MPGES inhibitors | 格辛塔制药公司 | 2021-03-05 | — | — | CN | disclosed |
| EP-3224253-B1 | BIS (SULFONAMIDE) DERIVATIVES AND THEIR USE AS MPGES INHIBITORS | GESYNTA PHARMA AB (SE) | 2019-10-30 | — | — | EP | disclosed |
| US-10227296-B2 | Bis(sulfonamide) derivatives and their use as mPGES inhibitors | Arcturum Real Estate AB (SE) | 2019-03-12 | — | — | US | disclosed |
| US-10227296-B2 | Bis(sulfonamide) derivatives and their use as mPGES inhibitors | Arcturum Real Estate AB (SE) | 2019-03-12 | — | — | US | disclosed |
| US-10081614-B2 | Bis(sulfonamide) derivatives and their use as mPGES inhibitors | ACTURUM REAL ESTATE AB (SE) | 2018-09-25 | — | — | US | disclosed |
| US-20180002278-A1 | BIS(SULFONAMIDE) DERIVATIVES AND THEIR USE AS MPGES INHIBITORS | ACTURUM REAL ESTATE AB (SE) | 2018-01-04 | — | — | US | disclosed |
| US-20180002278-A1 | BIS(SULFONAMIDE) DERIVATIVES AND THEIR USE AS MPGES INHIBITORS | ACTURUM REAL ESTATE AB (SE) | 2018-01-04 | — | — | US | disclosed |
| US-20170313672-A1 | BIS(SULFONAMIDE) DERIVATIVES AND THEIR USE AS MPGES INHIBITORS | GESYNTA PHARMA AB (SE) | 2017-11-02 | — | — | US | disclosed |
| US-20170313672-A1 | BIS(SULFONAMIDE) DERIVATIVES AND THEIR USE AS MPGES INHIBITORS | GESYNTA PHARMA AB (SE) | 2017-11-02 | — | — | US | disclosed |
| US-20170313672-A1 | BIS(SULFONAMIDE) DERIVATIVES AND THEIR USE AS MPGES INHIBITORS | GESYNTA PHARMA AB (SE) | 2017-11-02 | — | — | US | disclosed |
| EP-3224253-A1 | BIS(SULFONAMIDE) DERIVATIVES AND THEIR USE AS MPGES INHIBITORS | Acturum Real Estate AB (SE) | 2017-10-04 | — | — | EP | disclosed |
| EP-3224241-A1 | BIS(SULFONAMIDE) DERIVATIVES AND THEIR USE AS MPGES INHIBITORS | Acturum Real Estate AB (SE) | 2017-10-04 | — | — | EP | disclosed |
| WO-2016085391-A1 | BIS(SULFONAMIDE) DERIVATIVES AND THEIR USE AS MPGES INHIBITORS | Acturum Life Science AB (SE) | 2016-06-02 | — | — | WO | disclosed |
| WO-2016085392-A1 | BIS(SULFONAMIDE) DERIVATIVES AND THEIR USE AS MPGES INHIBITORS | Acturum Life Science AB (SE) | 2016-06-02 | — | — | WO | disclosed |
| WO-2016085391-A1 | BIS(SULFONAMIDE) DERIVATIVES AND THEIR USE AS MPGES INHIBITORS | Acturum Life Science AB (SE) | 2016-06-02 | — | — | WO | disclosed |
| US-8134001-B2 | Spiroindolinone derivatives | HOFFMANN-LA ROCHE INC. (US) | 2012-03-13 | — | — | US | disclosed |
| EP-2229396-B1 | SPIROINDOLINONE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2011-08-10 | — | — | EP | disclosed |
| EP-2229396-A1 | SPIROINDOLINONE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2010-09-22 | — | — | EP | disclosed |
| WO-2009077357-A1 | SPIROINDOLINONE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2009-06-25 | — | — | WO | disclosed |
| US-20090156610-A1 | Spiroindolinone Derivatives | DING QINGJIE | 2009-06-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090156610-A1 | Spiroindolinone Derivatives | SDHA, AR, XPOT | TDP1 3097/4885ERN1 2608/4885PTPN1 2799/4885 |
| US-10227296-B2 | Bis(sulfonamide) derivatives and their use as mPGES inhibitors | PTGES, PTGS1, PTGES2 | TDP1 2289/4885ERN1 1744/4885PTPN1 859/4885 |
| US-10081614-B2 | Bis(sulfonamide) derivatives and their use as mPGES inhibitors | PTGES, PTGS1, PTGES2 | TDP1 2289/4885ERN1 1744/4885PTPN1 859/4885 |
| US-20170313672-A1 | BIS(SULFONAMIDE) DERIVATIVES AND THEIR USE AS MPGES INHIBITORS | PTGES, PTGS1, PTGES2 | TDP1 2289/4885ERN1 1744/4885PTPN1 859/4885 |
| US-20180002278-A1 | BIS(SULFONAMIDE) DERIVATIVES AND THEIR USE AS MPGES INHIBITORS | PTGES, PTGS1, PTGES2 | TDP1 2289/4885ERN1 1744/4885PTPN1 859/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.