Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.44 |
| ▸ | MPL | P40238 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.39 |
| ▸ | RAB9A | P51151 | 5/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | NPC1 | O15118 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3193066 | 0.80 | CYP19A1 (0.53) | SMN1; SMN2ALDH1A1RAB9AKDM4ENPC1 | |
| SCHEMBL13510366 | 0.80 | HTR2B (0.55) | SMN1; SMN2HSD17B10ALDH1A1RAB9ANPC1 | |
| SCHEMBL4367505 | 0.78 | HSD17B10 (0.67) | ARSMN1; SMN2HSD17B10MPLALDH1A1 | |
| SCHEMBL13284002 | 0.76 | CYP19A1 (0.56) | SMN1; SMN2ALDH1A1RAB9AKDM4ENPC1 | |
| SCHEMBL2224538 | 0.75 | ALDH1A1 (0.55) | ARSMN1; SMN2ALDH1A1RAB9AKDM4E | |
| SCHEMBL13510369 | 0.74 | CYP19A1 (0.41) | SMN1; SMN2HSD17B10MPLRAB9AKDM4E | |
| SCHEMBL6366682 | 0.74 | RECQL (0.51) | ARSMN1; SMN2HSD17B10MPLALDH1A1 | |
| SCHEMBL7426136 | 0.73 | SMN1; SMN2 (0.53) | ARSMN1; SMN2HSD17B10MPLALDH1A1 | |
| SCHEMBL5822388 | 0.72 | MEN1 (0.32) | SMN1; SMN2HSD17B10ALDH1A1RAB9AKDM4E | |
| SCHEMBL4367503 | 0.72 | SMN1; SMN2 (0.55) | ARSMN1; SMN2HSD17B10MPLALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1399634-A | Hydroxyalkanoyl aminolactams and related structure as inhibitors of A beta protein production | BRISTOL MYERS SQUIBB PHARMA IN (US) | 2003-02-26 | — | — | CN | disclosed |