Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.53 |
| ▸ | AR | P10275 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.44 |
| ▸ | MPL | P40238 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 5/20 | 0.41 |
| ▸ | NPC1 | O15118 | 4/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4367503 | 0.92 | SMN1; SMN2 (0.55) | SMN1; SMN2ARHSD17B10MPLCYP3A4 | |
| SCHEMBL2221441 | 0.80 | ALDH1A1 (0.49) | SMN1; SMN2HSD17B10RAB9ANPC1ALDH1A1 | |
| SCHEMBL4367505 | 0.78 | HSD17B10 (0.67) | SMN1; SMN2ARHSD17B10MPLCYP3A4 | |
| SCHEMBL27458875 | 0.78 | PRKCZ (0.44) | SMN1; SMN2RAB9ANPC1ALDH1A1MAPT | |
| SCHEMBL6686667 | 0.75 | HTR2B (0.56) | SMN1; SMN2HSD17B10CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL27789995 | 0.75 | ALDH1A1 (0.55) | SMN1; SMN2HSD17B10CYP3A4CYP2C9RAB9A | |
| SCHEMBL10967054 | 0.75 | TYR (0.52) | SMN1; SMN2HSD17B10RAB9ANPC1TP53 | |
| SCHEMBL6664901 | 0.74 | ATP4A (0.58) | SMN1; SMN2CYP3A4CYP2D6CYP2C9SCN9A | |
| SCHEMBL6660568 | 0.74 | ATP4A (0.58) | SMN1; SMN2CYP3A4CYP2D6CYP2C9SCN9A | |
| SCHEMBL5999201 | 0.74 | MPL (0.61) | SMN1; SMN2MPLCYP3A4CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1399634-A | Hydroxyalkanoyl aminolactams and related structure as inhibitors of A beta protein production | BRISTOL MYERS SQUIBB PHARMA IN (US) | 2003-02-26 | — | — | CN | disclosed |
| EP-1212306-A2 | HYDROXYALKANOYLAMINOLACTAMS AND RELATED STRUCTURES AS INHIBITORS OF ABETA PROTEIN PRODUCTION | BRISTOL-MYERS SQUIBB COMPANY (US) | 2002-06-12 | — | — | EP | disclosed |
| WO-2001019797-A2 | HYDROXYALKANOYL AMINOLACTAMS AND RELATED STRUCTURES AS INHIBITORS OF Aβ PROTEIN PRODUCTION | DU PONT PHARMACEUTICALS COMPANY (US) | 2001-03-22 | — | — | WO | disclosed |
| CN-1129442-A | Benzodiazepine * derivatives | YAMANOUCHI PHARMA CO LTD (JP) | 1996-08-21 | — | — | CN | disclosed |