Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MIF | P14174 | 12/20 | 0.70 |
| ▸ | CD74 | P04233 | 7/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | TSHR | P16473 | 4/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | IDO1 | P14902 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2757853 | 0.85 | MIF (0.67) | MIFCD74L3MBTL1ALDH1A1TSHR | |
| SCHEMBL29566244 | 0.82 | MIF (1.00) | MIFCD74L3MBTL1ALDH1A1TSHR | |
| SCHEMBL3266381 | 0.82 | MIF (1.00) | MIFCD74L3MBTL1ALDH1A1TSHR | |
| SCHEMBL16554239 | 0.82 | MIF (0.70) | MIFCD74IDO1 | |
| SCHEMBL18805704 | 0.78 | MIF (0.81) | MIFCD74IDO1 | |
| SCHEMBL18805683 | 0.77 | MIF (1.00) | MIFCD74L3MBTL1ALDH1A1TSHR | |
| SCHEMBL11218178 | 0.74 | MIF (0.54) | MIFCD74TSHRHPGDUSP2 | |
| SCHEMBL2757834 | 0.74 | MIF (0.66) | MIFCD74L3MBTL1ALDH1A1TSHR | |
| SCHEMBL13086455 | 0.74 | MIF (1.00) | MIFCD74IDO1 | |
| SCHEMBL18805693 | 0.72 | MIF (0.82) | MIFCD74L3MBTL1ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180162813-A1 | MIF MODULATORS | YALE UNIVERSITY | 2018-06-14 | — | — | US | disclosed |
| US-9540322-B2 | MIF modulators | YALE UNIVERSITY (US) | 2017-01-10 | — | — | US | disclosed |
| US-20120040974-A1 | MIF MODULATORS | YALE UNIVERSITY (US) | 2012-02-16 | — | — | US | disclosed |
| US-20120004261-A1 | MIF MODULATORS | YALE UNIVERSITY (US) | 2012-01-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180162813-A1 | MIF MODULATORS | MIF, HMGB2, HMGB3 | MIF 1/4885CD74 15/4885L3MBTL1 2468/4885 |
| US-20120040974-A1 | MIF MODULATORS | MIF, HMGB2, HMGB3 | MIF 1/4885CD74 15/4885L3MBTL1 2468/4885 |
| US-20120004261-A1 | MIF MODULATORS | MIF, HMGB2, HMGB3 | MIF 1/4885CD74 15/4885L3MBTL1 2468/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.