Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CDK8 | P49336 | 1/20 | 0.31 |
| ▸ | SYK | P43405 | 1/20 | 0.31 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | RECQL | P46063 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27582085 | 0.82 | — | — | |
| SCHEMBL27561396 | 0.77 | ABCG2 (0.44) | CDK8SYKRAPGEF4 | |
| SCHEMBL7247542 | 0.70 | MAPT (0.45) | POLB | |
| SCHEMBL27564358 | 0.68 | PTGS1 (0.43) | POLBHSD17B10TSHR | |
| SCHEMBL5044897 | 0.68 | CYP1A2 (0.43) | P2RX7POLBCYP3A4 | |
| SCHEMBL27582103 | 0.68 | KDR (0.40) | CYP3A4TSHR | |
| SCHEMBL27561535 | 0.68 | ALPG (0.41) | POLBHSD17B10TSHR | |
| SCHEMBL3072732 | 0.67 | ALDH1A1 (0.52) | POLBCYP3A4 | |
| SCHEMBL7934011 | 0.67 | GAA (0.44) | POLBTSHR | |
| SCHEMBL93048 | 0.65 | S1PR1 (0.47) | POLBHSD17B10CYP3A4TSHRRECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1351498-A | Pyrrolotriazines inhibitors of kinases | BRISTOL MYERS SQUIBB CO (US) | 2002-05-29 | — | — | CN | claimed |