Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 2/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 4/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27561403 | 0.84 | PTGS1 (0.40) | PTGS1PTGS2TP53ALDH1A1MAPT | |
| SCHEMBL27564357 | 0.84 | ALDH3A1 (0.46) | TP53ALDH1A1SMN1; SMN2MAPTKMT2A | |
| SCHEMBL27561385 | 0.84 | TDP1 (0.38) | PTGS1PTGS2JAK2ALDH1A1SMN1; SMN2 | |
| SCHEMBL27582103 | 0.84 | KDR (0.40) | ALDH1A1MAPTKMT2ARAB9ANPC1 | |
| SCHEMBL27582035 | 0.82 | P2RY4 (0.40) | PTGS2TP53ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL27561674 | 0.80 | AR (0.36) | SMN1; SMN2MAPTKMT2AHPGDLMNA | |
| SCHEMBL27561375 | 0.79 | CA2 (0.42) | PTGS1PTGS2TP53LMNA | |
| SCHEMBL27561515 | 0.76 | EGFR (0.48) | PTGS2ALDH1A1SMN1; SMN2MAPTKMT2A | |
| SCHEMBL27576872 | 0.75 | RAPGEF4 (0.53) | ALDH1A1SMN1; SMN2MAPTKMT2ARAB9A | |
| SCHEMBL31549984 | 0.75 | ALDH1A1 (0.53) | TP53JAK2ALDH1A1SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1351498-A | Pyrrolotriazines inhibitors of kinases | BRISTOL MYERS SQUIBB CO (US) | 2002-05-29 | — | — | CN | claimed |