SCHEMBL27583263

SCHEMBL27583263

COC(=O)C(F)c1c[nH]c2c(C)cc(Cl)nc12

nearest known ligand 0.34

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
PNP P00491 1/20 0.34
LMNA P02545 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.31
CA12 O43570 1/20 0.30
CA1 P00915 1/20 0.30
CA2 P00918 1/20 0.30
CA9 Q16790 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27577034 0.74 KDM5A (0.42) PNPSMN1; SMN2
SCHEMBL1763696 0.73 NR4A2 (0.36) SMN1; SMN2
SCHEMBL27563129 0.70 MAPT (0.31)
SCHEMBL25024456 0.69 ROCK2 (0.37) LMNASMN1; SMN2
SCHEMBL30234055 0.69 ROCK2 (0.37) LMNASMN1; SMN2
SCHEMBL27583264 0.69 KDM5A (0.33) CA12CA1CA2CA9
SCHEMBL27583279 0.68 DYRK1A (0.35) PNPLMNA
SCHEMBL2628953 0.68 KMO (0.35) LMNASMN1; SMN2
SCHEMBL27614371 0.68 LMNA (0.34) LMNA
Potassium Ion SCHEMBL1763104 0.67 KMO (0.32) LMNASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1404392-A Antiviral azaindole derivatives BRISTOL MYERS SQUIBB CO (US) 2003-03-19 CN disclosed