Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 5/20 | 0.47 |
| ▸ | MAP2K2 | P36507 | 4/20 | 0.47 |
| ▸ | APP | P05067 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | METAP2 | P50579 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | RAD52 | P43351 | 1/20 | 0.38 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6951788 | 0.94 | MAP2K2 (0.46) | MAP2K1MAP2K2MEN1KMT2ATDP1 | |
| SCHEMBL27583296 | 0.87 | MAP2K1 (0.61) | MAP2K1MAP2K2MEN1KMT2ATDP1 | |
| SCHEMBL6035748 | 0.83 | MAP2K1 (0.44) | MAP2K1MAP2K2APPALDH1A1 | |
| SCHEMBL27469368 | 0.80 | MEN1 (0.51) | MAP2K1MAP2K2MEN1KMT2ATDP1 | |
| SCHEMBL6036183 | 0.79 | ALDH1A1 (0.46) | MAP2K1MAP2K2APPMEN1KMT2A | |
| SCHEMBL27508573 | 0.79 | MEN1 (0.47) | MAP2K1MAP2K2MEN1KMT2ATDP1 | |
| SCHEMBL27563907 | 0.79 | SMN1; SMN2 (0.56) | MAP2K1MAP2K2MEN1KMT2ATDP1 | |
| SCHEMBL6441683 | 0.78 | CXCL8 (0.48) | MAP2K1MAP2K2ALDH1A1KDM4EHPGD | |
| SCHEMBL6035363 | 0.78 | MAP2K1 (0.64) | MAP2K1MAP2K2MEN1KMT2ATDP1 | |
| SCHEMBL6035301 | 0.77 | MAP2K1 (0.71) | MAP2K1MAP2K2MEN1KMT2ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140291-B1 | COMBINATION CHEMOTHERAPY COMPRISING A MITOTIC INHIBITOR AND A MEK INHIBITOR | WARNER LAMBERT CO (US) | 2005-11-23 | — | — | EP | disclosed |