Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXAS1 | P24557 | 2/20 | 0.50 |
| ▸ | EIF4A3 | P38919 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | SRD5A2 | P31213 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | DAO | P14920 | 1/20 | 0.47 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.44 |
| ▸ | APEX1 | P27695 | 2/20 | 0.43 |
| ▸ | SMAD3 | P84022 | 1/20 | 0.42 |
| ▸ | RHEB | Q15382 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | F7 | P08709 | 1/20 | 0.41 |
| ▸ | F3 | P13726 | 1/20 | 0.41 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.41 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27590744 | 0.89 | SMAD3 (0.53) | TBXAS1KDM4EHSD17B10HPGDSRD5A2 | |
| SCHEMBL8985815 | 0.79 | TBXAS1 (0.57) | TBXAS1EIF4A3KDM4EHSD17B10HPGD | |
| SCHEMBL1144575 | 0.77 | DAO (0.58) | TBXAS1EIF4A3KDM4EHSD17B10HPGD | |
| SCHEMBL27858828 | 0.77 | TBXAS1 (0.50) | TBXAS1EIF4A3KDM4EHSD17B10HPGD | |
| SCHEMBL7881816 | 0.77 | PLA2G4A (0.58) | TBXAS1EIF4A3KDM4EHSD17B10HPGD | |
| SCHEMBL396212 | 0.76 | HRH4 (0.60) | EIF4A3KDM4EHSD17B10HPGDSRD5A2 | |
| SCHEMBL20494370 | 0.75 | HSD17B10 (0.60) | TBXAS1EIF4A3KDM4EHSD17B10HPGD | |
| SCHEMBL3031466 | 0.71 | KDM4E (0.55) | TBXAS1EIF4A3KDM4EHSD17B10HPGD | |
| SCHEMBL6753290 | 0.70 | TBXAS1 (0.55) | TBXAS1EIF4A3RXFP1 | |
| SCHEMBL1466749 | 0.70 | HDAC1 (0.48) | KDM4EMAPTF7F3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1522246-B | Triamide-substituted indoles, benzofurans and benzothiophenes | PFIZER | 2010-04-21 | — | — | CN | disclosed |
| CN-1880304-A | Triamide-substituted indoles, benzofuranes and benzothiophenes | PFIZER (US) | 2006-12-20 | — | — | CN | disclosed |
| CN-1522246-A | Triamide-substituted indoles, benzofurans and benzothiophenes as inhibitors of microsomal triglyceride transfer protein (MTP) and/or apolipoprotein B (APO B) secretion | �Ʒ� | 2004-08-18 | — | — | CN | disclosed |