Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXAS1 | P24557 | 2/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.56 |
| ▸ | HPGD | P15428 | 4/20 | 0.56 |
| ▸ | SRD5A2 | P31213 | 3/20 | 0.56 |
| ▸ | DAO | P14920 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | EIF4A3 | P38919 | 2/20 | 0.55 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.51 |
| ▸ | SMAD3 | P84022 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | F7 | P08709 | 1/20 | 0.47 |
| ▸ | F3 | P13726 | 1/20 | 0.47 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.47 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | APEX1 | P27695 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8360314 | 0.86 | SMAD3 (0.62) | TBXAS1HSD17B10KDM4EHPGDSRD5A2 | |
| SCHEMBL1144575 | 0.85 | DAO (0.58) | TBXAS1HSD17B10KDM4EHPGDSRD5A2 | |
| SCHEMBL20494370 | 0.82 | HSD17B10 (0.60) | TBXAS1HSD17B10KDM4EHPGDSRD5A2 | |
| SCHEMBL8985848 | 0.81 | ALOX15 (0.49) | KDM4EHPGDDAOMAPTALDH1A1 | |
| SCHEMBL27583744 | 0.79 | TBXAS1 (0.50) | TBXAS1HSD17B10KDM4EHPGDSRD5A2 | |
| SCHEMBL27858828 | 0.79 | TBXAS1 (0.50) | TBXAS1HSD17B10KDM4EHPGDSRD5A2 | |
| SCHEMBL7881816 | 0.79 | PLA2G4A (0.58) | TBXAS1HSD17B10KDM4EHPGDSRD5A2 | |
| SCHEMBL3031466 | 0.79 | KDM4E (0.55) | TBXAS1HSD17B10KDM4EHPGDSRD5A2 | |
| SCHEMBL28676411 | 0.79 | ALOX15 (0.68) | HSD17B10KDM4EHPGDDAOMAPT | |
| SCHEMBL3016664 | 0.77 | SMAD3 (0.73) | HSD17B10KDM4EHPGDSRD5A2DAO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5563142-A | INHIBITORS OF VIRAL REVERSE TRANSCRIPTASE | THE UPJOHN COMPANY (US) | 1996-10-08 | — | — | US | disclosed |
| EP-0507861-B1 | DIAROMATIC SUBSTITUTED ANTI-AIDS COMPOUNDS | UPJOHN CO (US) | 1996-09-11 | — | — | EP | disclosed |
| US-5489593-A | Anti-aids piperazines | THE UPJOHN COMPANY (US) | 1996-02-06 | — | — | US | disclosed |
| EP-0507861-A1 | DIAROMATIC SUBSTITUTED ANTI-AIDS COMPOUNDS. | UPJOHN CO (US) | 1992-10-14 | — | — | EP | disclosed |
| WO-1991009849-A1 | DIAROMATIC SUBSTITUTED ANTI-AIDS COMPOUNDS | THE UPJOHN COMPANY (US) | 1991-07-11 | — | — | WO | disclosed |