Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAPGEF3 | O95398 | 4/20 | 0.32 |
| ▸ | RAPGEF4 | Q8WZA2 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | GFER | P55789 | 1/20 | 0.30 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5743661 | 0.83 | GAA (0.37) | RAPGEF3RAPGEF4SMN1; SMN2MAPTTDP1 | |
| SCHEMBL3326397 | 0.83 | GAA (0.37) | RAPGEF3RAPGEF4SMN1; SMN2MAPTTDP1 | |
| SCHEMBL9192973 | 0.77 | ABCB1 (0.45) | RAPGEF3RAPGEF4MAPTMEN1CYP3A4 | |
| SCHEMBL6258551 | 0.75 | RAPGEF3 (0.38) | RAPGEF3RAPGEF4SMN1; SMN2MAPTTDP1 | |
| SCHEMBL6576619 | 0.71 | GAA (0.31) | SMN1; SMN2MAPTGAAKDM4EALDH1A1 | |
| SCHEMBL7744122 | 0.70 | NPSR1 (0.43) | RAPGEF3RAPGEF4SMN1; SMN2MAPTMEN1 | |
| SCHEMBL7744125 | 0.70 | NPSR1 (0.43) | RAPGEF3RAPGEF4SMN1; SMN2MAPTMEN1 | |
| SCHEMBL5713376 | 0.69 | GAA (0.35) | RAPGEF4MAPTKMT2AGAAKDM4E | |
| SCHEMBL6576612 | 0.69 | KDM4E (0.31) | SMN1; SMN2MAPTGAAKDM4EALDH1A1 | |
| SCHEMBL7736233 | 0.68 | RAPGEF3 (0.38) | RAPGEF3RAPGEF4SMN1; SMN2MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8288563-B2 | Process for the preparation of pyrazole derivatives | BASF SE (DE) | 2012-10-16 | — | — | US | disclosed |
| US-20120004421-A1 | Process for the preparation of pyrazole derivatives | BASF SE (DE) | 2012-01-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120004421-A1 | Process for the preparation of pyrazole derivatives | CBR3, CBR1, C1S | RAPGEF3 2533/4885RAPGEF4 3768/4885SMN1; SMN2 4065/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.