Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
| ▸ | MMP13 | P45452 | 1/20 | 0.30 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9606758 | 0.89 | HDAC1 (0.30) | HDAC1HDAC2HDAC6 | |
| SCHEMBL16281193 | 0.86 | HDAC6 (0.33) | HDAC1HDAC2HDAC6MMP13AAK1 | |
| SCHEMBL19390307 | 0.86 | HDAC6 (0.36) | HDAC1HDAC2HDAC6MMP13AAK1 | |
| SCHEMBL212413 | 0.83 | HDAC1 (0.31) | HDAC1HDAC2HDAC6MMP13AAK1 | |
| SCHEMBL2728629 | 0.83 | — | — | |
| SCHEMBL17571449 | 0.81 | HDAC6 (0.33) | HDAC1HDAC2HDAC6MMP13AAK1 | |
| SCHEMBL211564 | 0.80 | — | — | |
| SCHEMBL211563 | 0.80 | — | — | |
| SCHEMBL25467829 | 0.79 | HDAC6 (0.33) | HDAC1HDAC2HDAC6MMP13AAK1 | |
| SCHEMBL8196748 | 0.78 | AAK1 (0.40) | HDAC1HDAC2HDAC6MMP13AAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8088793-B2 | Certain chemical entities, compositions, and methods | CYTOKINETICS, INC. (US) | 2012-01-03 | — | — | US | disclosed |
| US-20090275537-A1 | Certain chemical entities, compositions, and methods | CYTOKINETICS, INC. | 2009-11-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090275537-A1 | Certain chemical entities, compositions, and methods | MYLK, MYH2, MYH10 | HDAC1 1823/4885HDAC2 1722/4885HDAC6 244/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.