Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SOST | Q9BQB4 | 1/20 | 0.61 |
| ▸ | TYMS | P04818 | 2/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.59 |
| ▸ | DHFR | P00374 | 3/20 | 0.59 |
| ▸ | MTHFD1 | P11586 | 3/20 | 0.57 |
| ▸ | MTHFD2 | P13995 | 2/20 | 0.56 |
| ▸ | GART | P22102 | 4/20 | 0.55 |
| ▸ | ATIC | P31939 | 3/20 | 0.55 |
| ▸ | FPGS | Q05932 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dihydrofolic Acid SCHEMBL8282 | 1.00 | SOST (0.61) | SOSTTYMSKDM4EMEN1ALDH1A1 | |
| Dihydrofolic Acid SCHEMBL8281 | 1.00 | SOST (0.61) | SOSTTYMSKDM4EMEN1ALDH1A1 | |
| Dihydrofolic Acid SCHEMBL12136386 | 1.00 | SOST (0.61) | SOSTTYMSKDM4EMEN1ALDH1A1 | |
| Dihydrofolic Acid SCHEMBL27415499 | 0.99 | SOST (0.60) | SOSTTYMSKDM4EMEN1ALDH1A1 | |
| Dihydrofolic Acid SCHEMBL27779274 | 0.98 | SOST (0.60) | SOSTTYMSKDM4EMEN1ALDH1A1 | |
| Dihydrofolic Acid SCHEMBL5159976 | 0.95 | SOST (0.59) | SOSTTYMSKDM4EMEN1ALDH1A1 | |
| Dihydrofolic Acid SCHEMBL29510656 | 0.95 | TYMS (0.56) | SOSTTYMSKDM4EMEN1ALDH1A1 | |
| Dihydrofolic Acid SCHEMBL28902275 | 0.95 | SOST (0.56) | SOSTTYMSKDM4EMEN1ALDH1A1 | |
| Dihydrofolic Acid SCHEMBL28796610 | 0.95 | SOST (0.56) | SOSTTYMSKDM4EMEN1ALDH1A1 | |
| Dihydrofolic Acid SCHEMBL31299576 | 0.93 | SOST (0.53) | SOSTTYMSKDM4EMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103209962-B | As the 6-amino-nicotinamide of the replacement of KCNQ2/3 conditioning agent | GRUNENTHAL GMBH (DE) | 2016-03-02 | — | — | CN | claimed |
| CN-103209962-A | Substituted 6-amino-nicotinamides as kcnq2/3 modulators | GRUENENTHAL GMBH | 2013-07-17 | — | — | CN | claimed |
| CN-102369188-B | As the replacement niacinamide of KCNQ2/3 conditioning agent | GRUNENTHAL GMBH (DE) | 2016-03-02 | — | — | CN | disclosed |
| CN-103209962-B | As the 6-amino-nicotinamide of the replacement of KCNQ2/3 conditioning agent | GRUNENTHAL GMBH (DE) | 2016-03-02 | — | — | CN | disclosed |
| CN-103209962-A | Substituted 6-amino-nicotinamides as kcnq2/3 modulators | GRUENENTHAL GMBH | 2013-07-17 | — | — | CN | disclosed |
| CN-101146532-B | Pharmaceutical compounds | ASTEX THERAPEUTICS LTD | 2012-05-09 | — | — | CN | disclosed |
| CN-101146532-A | Pharmaceutical compounds | ASTEX THERAPEUTICS LTD (GB) | 2008-03-19 | — | — | CN | disclosed |
| CN-1443180-A | Novel compounds having anti-inflammatory activity, process for their preparation and pharmaceutical compositions containing them | REDDY LAB LTD (IN) | 2003-09-17 | — | — | CN | disclosed |