Dihydrofolic Acid

Dihydrofolic Acid

SCHEMBL8282

Nc1nc2c(c(=O)[nH]1)N=C(CNc1ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc1)CN2

nearest known ligand 0.61

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SOST Q9BQB4 1/20 0.61
TYMS P04818 2/20 0.59
KDM4E B2RXH2 1/20 0.59
MEN1 O00255 1/20 0.59
ALDH1A1 P00352 1/20 0.59
POLB P06746 1/20 0.59
GAA P10253 1/20 0.59
AKR1B1 P15121 1/20 0.59
HPGD P15428 1/20 0.59
TSHR P16473 1/20 0.59
PTGS2 P35354 1/20 0.59
KMT2A Q03164 1/20 0.59
HSD17B10 Q99714 1/20 0.59
TDP1 Q9NUW8 1/20 0.59
DHFR P00374 3/20 0.59
MTHFD1 P11586 3/20 0.57
MTHFD2 P13995 2/20 0.56
GART P22102 4/20 0.55
ATIC P31939 3/20 0.55
FPGS Q05932 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Dihydrofolic Acid SCHEMBL8281 1.00 SOST (0.61) SOSTTYMSKDM4EMEN1ALDH1A1
Dihydrofolic Acid SCHEMBL12136386 1.00 SOST (0.61) SOSTTYMSKDM4EMEN1ALDH1A1
Dihydrofolic Acid SCHEMBL27589172 1.00 SOST (0.61) SOSTTYMSKDM4EMEN1ALDH1A1
Dihydrofolic Acid SCHEMBL27415499 0.99 SOST (0.60) SOSTTYMSKDM4EMEN1ALDH1A1
Dihydrofolic Acid SCHEMBL27779274 0.98 SOST (0.60) SOSTTYMSKDM4EMEN1ALDH1A1
Dihydrofolic Acid SCHEMBL5159976 0.95 SOST (0.59) SOSTTYMSKDM4EMEN1ALDH1A1
Dihydrofolic Acid SCHEMBL29510656 0.95 TYMS (0.56) SOSTTYMSKDM4EMEN1ALDH1A1
Dihydrofolic Acid SCHEMBL28902275 0.95 SOST (0.56) SOSTTYMSKDM4EMEN1ALDH1A1
Dihydrofolic Acid SCHEMBL28796610 0.95 SOST (0.56) SOSTTYMSKDM4EMEN1ALDH1A1
Dihydrofolic Acid SCHEMBL31299576 0.93 SOST (0.53) SOSTTYMSKDM4EMEN1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1375 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4747627-A1 METHODS AND SYSTEMS FOR PREDICTIVE CLASSIFICATION BY MASS SPECTROMETRY AND TRAINED LARGE SPECTRAL MODELS Matterworks Inc (US) 2026-05-27 EP claimed
EP-3495487-B1 PROMOTER WITH A REGION RICH IN CYTOSINE-GUANINE DINUCLEOTIDES, VECTORS, CELLULAR LINES, METHOD FOR PRODUCING RECOMBINANT PROTEIN UNIV CHILE (CL) 2026-04-29 EP claimed
EP-4282978-B1 A UNIVERSAL PLATFORM FOR CAR THERAPY TARGETING A NOVEL ANTIGENIC SIGNATURE OF CANCER GAVISH GALILEE BIO APPL LTD (IL) 2026-04-01 EP claimed
EP-3678682-B1 METHODS, COMPOSITIONS AND CELLS FOR PREPARING SURFACTANT PROTEIN D (SP-D) AIRWAY THERAPEUTICS INC (US) 2026-04-01 EP claimed
EP-4182467-B1 RECOMBINANT ADENO-ASSOCIATED VIRAL VECTORS FOR MULTIPARTITE GENE DELIVERY ABEONA THERAPEUTICS INC (US) 2026-02-11 EP claimed
EP-3551657-B1 CHIMERIC CHLOROTOXIN RECEPTORS UAB RES FOUND (US) 2026-02-04 EP claimed
US-20260028717-A1 METHOD FOR PREPARING METALLIC COBALT THIN FILM AND METHOD FOR PREPARING COBALT SILICIDE THIN FILM INST OF MICROELECTRONICS CAS (CN) 2026-01-29 US claimed
EP-4676472-A2 BI-SPECIFIC ADAPTERS AND THEIR USE WITH UNIVERSAL CAR-T CELLS IN THE TREATMENT OF TUMORS AND THE INHIBITION OF CANCER-ASSOCIATED FIBROBLASTS Purdue Research Foundation (US) 2026-01-14 EP claimed
EP-3953480-B1 TRANSPOSITION OF NUCLEIC ACIDS INTO EUKARYOTIC GENOMES WITH A TRANSPOSASE FROM HELIOTHIS DNA TWOPOINTO INC (US) 2025-12-03 EP claimed
EP-3625238-B1 NOVEL SPIRO-LACTAM COMPOUNDS, PROCESS AND USES THEREOF UNIV DE COIMBRA (PT) 2025-11-26 EP claimed
US-20110244575-A1 METHODS, SYSTEMS AND COMPOSITIONS FOR INCREASED MICROORGANISM TOLERANCE TO AND PRODUCTION OF 3-HYDROXYPROPIONIC ACID (3-HP) OPX BIOTECHNOLOGIES, INC. 2011-10-06 US claimed
US-20100210017-A1 COMPOSITIONS AND METHODS FOR ENHANCING TOLERANCE FOR THE PRODUCTION OF ORGANIC CHEMICALS PRODUCED BY MICROORGANISMS THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE 2010-08-19 US claimed
US-20100143911-A1 METHOD FOR SCREENING ESSENTIAL METABOLITES IN GROWTH OF MICROORGANISMS KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) 2010-06-10 US claimed
EP-2126042-A2 COMPOSITIONS AND METHODS FOR ENHANCING TOLERANCE FOR THE PRODUCTION OF ORGANIC CHEMICALS PRODUCED BY MICROORGANISMS The Regents of the University of Colorado (US) 2009-12-02 EP claimed
EP-2097743-A1 METHOD FOR SCREENING ESSENTIAL METABOLITES IN GROWTH OF MICROORGANISMS Korea Advanced Institute of Science and Technology (KR) 2009-09-09 EP claimed
WO-2008089102-A2 COMPOSITIONS AND METHODS FOR ENHANCING TOLERANCE FOR THE PRODUCTION OF ORGANIC CHEMICALS PRODUCED BY MICROORGANISMS REGENTS OF THE UNIVERSITY OF COLORADO (US) 2008-07-24 WO claimed
WO-2008078911-A1 METHOD FOR SCREENING ESSENTIAL METABOLITES IN GROWTH OF MICROORGANISMS KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) 2008-07-03 WO claimed
WO-2001077366-A1 POSITIVE SELECTION METHOD, COMPOUNDS, HOST CELLS AND USES THEREOF CUBIST PHARMACEUTICALS, INC. (US) 2001-10-18 WO claimed
US-5872104-A BACTERICIDES AND RESISTANT BACTERIA WITH METHYLATION INHIBITORS ORIDIGM CORPORATION (US) 1999-02-16 US claimed
WO-1996020010-A1 COMBINATION FOR REDUCING ANTIMICROBIAL RESISTANCE USING A METHYLATION INHIBITOR IN COMBINATION WITH AN ANTIBIOTIC ORIDIGM CORPORATION (US) 1996-07-04 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260028717-A1 METHOD FOR PREPARING METALLIC COBALT THIN FILM AND METHOD FOR PREPARING COBALT SILICIDE THIN FILM CDH1, DCAF1, ADH1C SOST 748/4885TYMS 3801/4885KDM4E 2212/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.