Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Dihydrofolic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 known ✓ | P35354 | 1/20 | 0.58 |
| ▸ | DHFR known ✓ | P00374 | 3/20 | 0.57 |
| ▸ | GART known ✓ | P22102 | 4/20 | 0.54 |
| ▸ | SOST | Q9BQB4 | 1/20 | 0.60 |
| ▸ | TYMS | P04818 | 2/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
| ▸ | MTHFD1 | P11586 | 3/20 | 0.56 |
| ▸ | MTHFD2 | P13995 | 2/20 | 0.54 |
| ▸ | ATIC | P31939 | 3/20 | 0.53 |
| ▸ | FPGS | Q05932 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dihydrofolic Acid SCHEMBL8282 | 0.98 | SOST (0.61) | SOSTTYMSKDM4EMEN1ALDH1A1 | |
| Dihydrofolic Acid SCHEMBL12136386 | 0.98 | SOST (0.61) | SOSTTYMSKDM4EMEN1ALDH1A1 | |
| Dihydrofolic Acid SCHEMBL27589172 | 0.98 | SOST (0.61) | SOSTTYMSKDM4EMEN1ALDH1A1 | |
| Dihydrofolic Acid SCHEMBL8281 | 0.98 | SOST (0.61) | SOSTTYMSKDM4EMEN1ALDH1A1 | |
| Dihydrofolic Acid SCHEMBL27415499 | 0.98 | SOST (0.60) | SOSTTYMSKDM4EMEN1ALDH1A1 | |
| Dihydrofolic Acid SCHEMBL5159976 | 0.94 | SOST (0.59) | SOSTTYMSKDM4EMEN1ALDH1A1 | |
| Dihydrofolic Acid SCHEMBL29510656 | 0.93 | TYMS (0.56) | SOSTTYMSKDM4EMEN1ALDH1A1 | |
| Dihydrofolic Acid SCHEMBL28902275 | 0.93 | SOST (0.56) | SOSTTYMSKDM4EMEN1ALDH1A1 | |
| Dihydrofolic Acid SCHEMBL28796610 | 0.93 | SOST (0.56) | SOSTTYMSKDM4EMEN1ALDH1A1 | |
| Dihydrofolic Acid SCHEMBL31299576 | 0.91 | SOST (0.53) | SOSTTYMSKDM4EMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101531661-B | Preparation method of tetrahydrofolic acid | Hubei Qinduankou Prison | 2011-01-19 | — | — | CN | claimed |
| CN-101531661-A | Preparation method of tetrahydrofolic acid | Hubei Qinduankou Prison | 2009-09-16 | — | — | CN | claimed |
| CN-101531661-B | Preparation method of tetrahydrofolic acid | Hubei Qinduankou Prison | 2011-01-19 | — | — | CN | disclosed |
| CN-101531661-A | Preparation method of tetrahydrofolic acid | Hubei Qinduankou Prison | 2009-09-16 | — | — | CN | disclosed |