Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | GRK6 | P43250 | 1/20 | 0.36 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3893912 | 0.90 | KMT2A (0.56) | KMT2ALMNASMN1; SMN2TP53ATM | |
| SCHEMBL33921 | 0.88 | CYP2C19 (0.47) | KMT2ALMNASMN1; SMN2TP53ATM | |
| SCHEMBL2759029 | 0.85 | SLC2A1 (0.50) | KMT2ALMNASMN1; SMN2TP53ATM | |
| SCHEMBL2759083 | 0.81 | KMT2A (0.69) | KMT2ALMNASMN1; SMN2TP53ATM | |
| SCHEMBL2759024 | 0.81 | KMT2A (0.53) | KMT2ALMNASMN1; SMN2TP53ATM | |
| SCHEMBL21146474 | 0.81 | KMT2A (0.49) | KMT2ALMNASMN1; SMN2TP53ATM | |
| SCHEMBL17122222 | 0.81 | CYP2C19 (0.41) | KMT2ALMNASMN1; SMN2TP53ATM | |
| SCHEMBL903672 | 0.81 | CYP2C19 (0.41) | KMT2ALMNASMN1; SMN2NPSR1MAPT | |
| SCHEMBL22415867 | 0.80 | SLC2A1 (0.45) | KMT2ALMNASMN1; SMN2TP53ATM | |
| SCHEMBL18708852 | 0.79 | GRK6 (0.54) | MAPTHTTALDH1A1TDP1CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9828330-B2 | Non-peptide BDNF neurotrophin mimetics | PHARMATROPHIX, INC. (US) | 2017-11-28 | — | — | US | disclosed |
| US-9604907-B2 | Methods of facilitating neural cell survival using non-peptide and peptide BDNF neurotrophin mimetics | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2017-03-28 | — | — | US | disclosed |
| US-20160046559-A1 | NON-PEPTIDE BDNF NEUROTROPHIN MIMETICS | PHARMATROPHIX, INC. (US) | 2016-02-18 | — | — | US | disclosed |
| US-20140296343-A1 | NON-PEPTIDE BDNF NEUROTROPHIN MIMETICS | PHARMATROPHIX, INC. | 2014-10-02 | — | — | US | disclosed |
| US-20120004310-A1 | NON-PEPTIDE BDNF NEUROTROPHIN MIMETICS | PHARMATROPHIX, INC. | 2012-01-05 | — | — | US | disclosed |
| US-20070060526-A1 | Methods of facilitating neural cell survival using non-peptide and peptide BDNF neurotrophin mimetics | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2007-03-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070060526-A1 | Methods of facilitating neural cell survival using non-peptide and peptide BDNF neurotrophin mimetics | BDNF, NTRK2, NGF | KMT2A 3874/4885LMNA 2218/4885SMN1; SMN2 5/4885 |
| US-20120004310-A1 | NON-PEPTIDE BDNF NEUROTROPHIN MIMETICS | BDNF, NTRK2, NGF | KMT2A 3890/4885LMNA 3046/4885SMN1; SMN2 34/4885 |
| US-20160046559-A1 | NON-PEPTIDE BDNF NEUROTROPHIN MIMETICS | NTRK2, BDNF, NTRK1 | KMT2A 3852/4885LMNA 2805/4885SMN1; SMN2 47/4885 |
| US-20140296343-A1 | NON-PEPTIDE BDNF NEUROTROPHIN MIMETICS | BDNF, NTRK2, NGF | KMT2A 3890/4885LMNA 3046/4885SMN1; SMN2 34/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.