Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B1 | P14061 | 11/20 | 0.50 |
| ▸ | HSD17B2 | P37059 | 11/20 | 0.50 |
| ▸ | HPGDS | O60760 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2158088 | 0.76 | — | — | |
| SCHEMBL5842337 | 0.75 | HPGDS (0.69) | HSD17B1HSD17B2HPGDSMEN1POLB | |
| SCHEMBL3814674 | 0.72 | GAA (0.40) | HSD17B1HSD17B2 | |
| SCHEMBL3756385 | 0.69 | POLB (0.70) | HSD17B1HSD17B2HPGDSMEN1POLB | |
| SCHEMBL2157712 | 0.67 | — | — | |
| SCHEMBL1761545 | 0.67 | RAB9A (0.92) | HPGDSMEN1POLBRAB9AKMT2A | |
| SCHEMBL24573407 | 0.67 | HPGD (0.66) | HSD17B1HSD17B2MEN1POLBRAB9A | |
| SCHEMBL6260315 | 0.66 | RAB9A (0.83) | HPGDSMEN1POLBRAB9AKMT2A | |
| SCHEMBL5605082 | 0.65 | HSD17B1 (0.60) | HSD17B1HSD17B2HPGDS | |
| SCHEMBL3639170 | 0.65 | HPGDS (1.00) | HSD17B1HSD17B2HPGDSMEN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1602308-A | Thiophene derivatives as antiviral agents against flavivirus infections | VIRUS CHEM PHARMA INC (CA) | 2005-03-30 | — | — | CN | claimed |
| CN-101624391-A | Thiophene derivatives as antiviral agents for flavivirus infection | VIROCHEM PHARMA INC | 2010-01-13 | — | — | CN | disclosed |
| CN-100509797-C | Thiophene derivatives as antiviral agents against flavivirus infections | VIRUS CHEM PHARMA INC (CA) | 2009-07-08 | — | — | CN | disclosed |
| CN-1602308-A | Thiophene derivatives as antiviral agents against flavivirus infections | VIRUS CHEM PHARMA INC (CA) | 2005-03-30 | — | — | CN | disclosed |