Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | TTK | P33981 | 2/20 | 0.46 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | IDO1 | P14902 | 2/20 | 0.46 |
| ▸ | ALPL | P05186 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | HTR2C | P28335 | 1/20 | 0.45 |
| ▸ | HTR2B | P41595 | 1/20 | 0.45 |
| ▸ | MAP2K4 | P45985 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.41 |
| ▸ | STAT3 | P40763 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.41 |
| ▸ | FLT3 | P36888 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL276725 | 0.90 | KDM4E (0.58) | KDM4EGAAPDPK1CYP3A4TTK | |
| Hydrochloric Acid SCHEMBL28343698 | 0.88 | KDM4E (0.56) | KDM4EGAAPDPK1CYP3A4TTK | |
| SCHEMBL9041896 | 0.74 | CYP1A2 (0.61) | KDM4EGAAPDPK1CYP3A4TTK | |
| SCHEMBL1132419 | 0.69 | KDM4E (0.54) | KDM4EGAAPDPK1CYP3A4TTK | |
| SCHEMBL29468202 | 0.69 | KDM4E (0.54) | KDM4EGAAPDPK1CYP3A4TTK | |
| SCHEMBL29869220 | 0.69 | HTR2C (0.50) | KDM4EGAAPDPK1CYP3A4TTK | |
| SCHEMBL1545976 | 0.69 | HTR2C (0.50) | KDM4EGAAPDPK1CYP3A4TTK | |
| Piperazine SCHEMBL1544743 | 0.68 | TTK (0.43) | KDM4EGAAPDPK1CYP3A4TTK | |
| Hydrochloric Acid SCHEMBL5767318 | 0.68 | KDM4E (0.56) | KDM4EGAAPDPK1CYP3A4TTK | |
| Carbazole SCHEMBL4589761 | 0.68 | ALDH1A1 (0.74) | KDM4EGAAALDH1A1IDO1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100377003-C | Photography treatment composition and image formation method using same | FUJI PHOTO FILM CO LTD (JP) | 2008-03-26 | — | — | CN | disclosed |
| CN-1438541-A | Photography treatment composition and image formation method using same | FUJI PHOTO FILM CO LTD (JP) | 2003-08-27 | — | — | CN | disclosed |