Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Carbazole. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.74 |
| ▸ | GPR3 | P46089 | 2/20 | 0.74 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.74 |
| ▸ | AHR | P35869 | 1/20 | 0.61 |
| ▸ | HTR2A | P28223 | 2/20 | 0.55 |
| ▸ | HTR2C | P28335 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | GLA | P06280 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | ATM | Q13315 | 1/20 | 0.54 |
| ▸ | KIF11 | P52732 | 5/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | GABRP | O00591 | 2/20 | 0.50 |
| ▸ | GABRD | O14764 | 2/20 | 0.50 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.50 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Carbazole SCHEMBL28297616 | 0.97 | ALDH1A1 (0.78) | ALDH1A1GPR3HSD17B10AHRHTR2A | |
| Carbazole SCHEMBL28173066 | 0.89 | ALDH1A1 (0.93) | ALDH1A1GPR3HSD17B10AHRKDM4E | |
| Carbazole SCHEMBL22364217 | 0.88 | ALDH1A1 (0.64) | ALDH1A1GPR3HSD17B10AHRHTR2A | |
| Carbazole SCHEMBL370524 | 0.86 | ALDH1A1 (1.00) | ALDH1A1GPR3HSD17B10AHRKDM4E | |
| Carbazole SCHEMBL30209164 | 0.86 | ALDH1A1 (1.00) | ALDH1A1GPR3HSD17B10AHRKDM4E | |
| Carbazole SCHEMBL29355407 | 0.86 | ALDH1A1 (1.00) | ALDH1A1GPR3HSD17B10AHRKDM4E | |
| Carbazole SCHEMBL29627417 | 0.86 | ALDH1A1 (1.00) | ALDH1A1GPR3HSD17B10AHRKDM4E | |
| Carbazole SCHEMBL30761795 | 0.86 | ALDH1A1 (1.00) | ALDH1A1GPR3HSD17B10AHRKDM4E | |
| Carbazole SCHEMBL7650 | 0.86 | ALDH1A1 (1.00) | ALDH1A1GPR3HSD17B10AHRKDM4E | |
| Carbazole SCHEMBL26134117 | 0.86 | ALDH1A1 (1.00) | ALDH1A1GPR3HSD17B10AHRKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106532094-B | A kind of lithium sulphur flow battery | 中科派思储能技术有限公司 | 2019-08-16 | — | — | CN | claimed |
| US-20080311051-A1 | Caspase-2 Inhibitors And Their Biological Applications | THERAPTOSIS SA (FR) | 2008-12-18 | — | — | US | claimed |
| CN-109476811-A | One-part low temperature cure coating formed via a dual layer cure mechanism | 巴斯夫涂料有限公司 | 2019-03-15 | — | — | CN | disclosed |
| CN-109476933-A | The low temperature solidification coating formed via the water base base of coloring and the double-deck curing mechanism of solvent base top layer | 巴斯夫涂料有限公司 | 2019-03-15 | — | — | CN | disclosed |
| CN-109206431-A | Organic electroluminescent compounds and its application and organic electroluminescence device | 北京绿人科技有限责任公司 | 2019-01-15 | — | — | CN | disclosed |
| CN-108727902-A | Inorganic nano material prints ink and preparation method thereof | TCL集团股份有限公司 | 2018-11-02 | — | — | CN | disclosed |
| CN-108727896-A | Inorganic nano material prints ink and preparation method thereof | TCL集团股份有限公司 | 2018-11-02 | — | — | CN | disclosed |
| CN-108624135-A | Inorganic nano material prints ink and preparation method thereof | TCL集团股份有限公司 | 2018-10-09 | — | — | CN | disclosed |
| CN-108624136-A | Inorganic nano material prints ink and preparation method thereof | TCL集团股份有限公司 | 2018-10-09 | — | — | CN | disclosed |
| CN-108624134-A | Inorganic nano material prints ink and preparation method thereof | TCL集团股份有限公司 | 2018-10-09 | — | — | CN | disclosed |
| CN-108570259-A | Inorganic nano material prints ink and preparation method thereof | TCL集团股份有限公司 | 2018-09-25 | — | — | CN | disclosed |
| CN-108409774-A | Organic electroluminescent compounds and its application and organic electroluminescence device | 北京绿人科技有限责任公司 | 2018-08-17 | — | — | CN | disclosed |
| CN-108250886-A | Coating composition for coating a substrate comprising a binder component | 涂层国外知识产权有限公司 | 2018-07-06 | — | — | CN | disclosed |
| CN-1847344-A | Low bake melamine cured coating compositions | ROHM & HAAS (US) | 2006-10-18 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080311051-A1 | Caspase-2 Inhibitors And Their Biological Applications | CASP1, CASP2, CASP9 | ALDH1A1 2650/4885GPR3 4458/4885HSD17B10 1889/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.