Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | SERPINE1 | P05121 | 3/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.41 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.40 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27615861 | 0.89 | RAB9A (0.42) | SMN1; SMN2RAB9ANPC1ALDH1A1RXFP1 | |
| SCHEMBL5562371 | 0.88 | SERPINE1 (0.40) | SMN1; SMN2RAB9ANPC1ALDH1A1SERPINE1 | |
| SCHEMBL27597139 | 0.86 | ALDH1A1 (0.48) | SMN1; SMN2RAB9ANPC1ALDH1A1SCN5A | |
| SCHEMBL27615911 | 0.85 | WNT3A (0.44) | SMN1; SMN2RAB9ANPC1ALDH1A1SERPINE1 | |
| SCHEMBL27615863 | 0.84 | RAB9A (0.46) | SMN1; SMN2RAB9ANPC1ALDH1A1SERPINE1 | |
| SCHEMBL27597149 | 0.83 | SERPINE1 (0.43) | SMN1; SMN2RAB9ANPC1ALDH1A1SERPINE1 | |
| SCHEMBL27597111 | 0.82 | SCN5A (0.50) | SMN1; SMN2RAB9ANPC1ALDH1A1SCN5A | |
| SCHEMBL27615831 | 0.82 | SCN5A (0.41) | SMN1; SMN2RAB9ANPC1ALDH1A1SCN5A | |
| SCHEMBL27597178 | 0.81 | MKNK1 (0.49) | PTGER1SCN5ASCN9A | |
| SCHEMBL27615839 | 0.79 | SCN5A (0.47) | SMN1; SMN2RAB9ANPC1ALDH1A1SCN5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100497333-C | Dihydrobenzodiazepin-2-one derivatives for the treatment of neurological disorders | HOFFMANN LA ROCHE (CH) | 2009-06-10 | — | — | CN | disclosed |
| CN-1633430-A | Dihydrobenzodiazepin-2-one derivatives for the treatment of neurological disorders | HOFFMANN LA ROCHE (CH) | 2005-06-29 | — | — | CN | disclosed |