Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | RAD52 | P43351 | 1/20 | 0.38 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.37 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 3/20 | 0.35 |
| ▸ | HTR1D | P28221 | 3/20 | 0.35 |
| ▸ | HTR1B | P28222 | 3/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.34 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.34 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4078469 | 0.79 | GAA (0.45) | HSD11B1TDP1L3MBTL1KDM4E | |
| SCHEMBL27599866 | 0.79 | ALDH1A1 (0.47) | L3MBTL1ALOX5KDM4E | |
| SCHEMBL27618397 | 0.77 | HTR1A (0.37) | MTNR1AMTNR1BHTR1AHTR1DHTR1B | |
| SCHEMBL27821075 | 0.77 | HSD11B1 (0.43) | HSD11B1TDP1HTR1AHTR1DHTR1B | |
| SCHEMBL27799850 | 0.77 | HSD11B1 (0.43) | HSD11B1HTR1AHTR1DHTR1BCXCR2 | |
| SCHEMBL27599865 | 0.76 | RAD52 (0.45) | RAD52TDP1L3MBTL1SIRT5KDM4E | |
| SCHEMBL27665035 | 0.74 | HSD11B1 (0.43) | HSD11B1RAD52MTNR1AMTNR1BHTR1A | |
| SCHEMBL27797837 | 0.74 | MEN1 (0.45) | — | |
| SCHEMBL2654823 | 0.73 | NQO2 (0.49) | HSD11B1KDM4E | |
| SCHEMBL6989892 | 0.72 | CDYL (0.53) | RAD52MTNR1ATDP1L3MBTL1SIRT5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100351251-C | Indolylmaleimide derivatives | NOVARTIS AG (CH) | 2007-11-28 | — | — | CN | disclosed |
| CN-1639153-A | Indolylmaleimide derivatives | NOVARTIS AG (CH) | 2005-07-13 | — | — | CN | disclosed |