Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 1/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 8/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.47 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.47 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.47 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.47 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.47 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.47 |
| ▸ | THRA | P10827 | 4/20 | 0.47 |
| ▸ | THRB | P10828 | 4/20 | 0.47 |
| ▸ | BDKRB2 | P30411 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11133367 | 0.89 | HDAC6 (0.55) | CNR2HDAC6HDAC3HDAC4HDAC1 | |
| SCHEMBL24505748 | 0.84 | ALDH1A1 (0.53) | CNR2HDAC6HDAC3HDAC4HDAC1 | |
| SCHEMBL8391468 | 0.83 | HSD17B3 (0.56) | CNR2HDAC6HDAC3HDAC4HDAC1 | |
| SCHEMBL11133366 | 0.83 | TP53 (0.53) | CNR2HDAC6HDAC3HDAC4HDAC1 | |
| SCHEMBL27619398 | 0.81 | HDAC6 (0.49) | CNR2HDAC6HDAC3HDAC4HDAC1 | |
| SCHEMBL5178440 | 0.81 | HDAC6 (0.57) | HDAC6HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL24673682 | 0.81 | L3MBTL1 (0.49) | CNR2HDAC6HDAC3HDAC4HDAC1 | |
| SCHEMBL7517981 | 0.81 | HDAC6 (0.57) | HDAC6HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL24607683 | 0.81 | ALDH1A1 (0.51) | CNR2HDAC6HDAC3HDAC1HDAC2 | |
| SCHEMBL3709914 | 0.80 | LOXL2 (0.50) | HDAC6HDAC3HDAC4HDAC1NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100410236-C | Substituted methylene amide derivatives as protein tyrosine phosphatase modulators | APPLIED RESEARCH SYSTEMS (CH) | 2008-08-13 | — | — | CN | claimed |
| CN-1933827-A | Use of methylene amide derivatives in cardiovascular disorders | APPLIED RESEARCH SYSTEMS (AN) | 2007-03-21 | — | — | CN | claimed |
| CN-1633410-A | Substituted methylene amide derivatives as protein tyrosine phosphatase modulators | APPLIED RESEARCH SYSTEMS (AN) | 2005-06-29 | — | — | CN | claimed |
| CN-1933827-B | Use of methylene amide derivatives in preparing medicine for treating and/ or preventing heart failure | SERONO LAB | 2011-07-27 | — | — | CN | disclosed |
| CN-1933827-A | Use of methylene amide derivatives in cardiovascular disorders | APPLIED RESEARCH SYSTEMS (AN) | 2007-03-21 | — | — | CN | disclosed |