Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.58 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.49 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.46 |
| ▸ | HTR3B | O95264 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | THPO | P40225 | 1/20 | 0.46 |
| ▸ | HTR3A | P46098 | 1/20 | 0.46 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.46 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.46 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.46 |
| ▸ | PDE10A | Q9Y233 | 9/20 | 0.45 |
| ▸ | DPP4 | P27487 | 1/20 | 0.44 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.44 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.44 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.44 |
| ▸ | SORD | Q00796 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3054821 | 0.89 | HRH3 (0.59) | KDM4EALDH1A1CYP3A4HSD17B10HRH3 | |
| SCHEMBL5832930 | 0.85 | HRH3 (0.63) | KDM4EALDH1A1HRH3HTR3EHTR3B | |
| SCHEMBL3537832 | 0.82 | HRH3 (0.61) | KDM4EALDH1A1CYP3A4HSD17B10HRH3 | |
| Fumaric Acid SCHEMBL27601356 | 0.80 | HTR3A (0.44) | KDM4EALDH1A1HTR3ADPP4 | |
| Fumaric Acid SCHEMBL28752216 | 0.80 | NOTUM (0.50) | KDM4EHRH3 | |
| Maleic Acid SCHEMBL29868216 | 0.78 | KDM4E (1.00) | KDM4EALDH1A1CYP3A4HSD17B10HRH3 | |
| Fumaric Acid SCHEMBL27491917 | 0.77 | LMNA (0.53) | CYP1A2 | |
| Fumaric Acid SCHEMBL1024084 | 0.77 | LMNA (0.36) | KDM4EALDH1A1HRH3 | |
| SCHEMBL3384524 | 0.77 | HRH3 (0.61) | KDM4EALDH1A1CYP3A4HSD17B10HRH3 | |
| SCHEMBL16695318 | 0.74 | NOTUM (0.57) | KDM4EALDH1A1CYP3A4HSD17B10HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100398103-C | Treatment of affective disorders by the combined action of a nicotinic receptor agonist and a monoaminergic substance | NEUROSEARCH AS (DK) | 2008-07-02 | — | — | CN | disclosed |
| CN-1635877-A | Treatment of affective disorders by the combined action of a nicotinic receptor agonist and a monoaminergic substance | NEUROSEARCH AS (DK) | 2005-07-06 | — | — | CN | disclosed |