Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Dapsone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.73 |
| ▸ | HTR6 | P50406 | 3/20 | 0.73 |
| ▸ | LMNA | P02545 | 1/20 | 0.73 |
| ▸ | MPO | P05164 | 1/20 | 0.73 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.73 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.73 |
| ▸ | PKM | P14618 | 3/20 | 0.67 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.67 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | NPC1 | O15118 | 1/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.57 |
| ▸ | DHFR | P00374 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | PRMT1 | Q99873 | 3/20 | 0.54 |
| ▸ | NT5E | P21589 | 1/20 | 0.54 |
| ▸ | CA1 | P00915 | 2/20 | 0.50 |
| ▸ | CA2 | P00918 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dapsone SCHEMBL28433097 | 0.91 | TSHR (0.67) | TSHRHTR6LMNAMPOCYP3A4 | |
| Dapsone SCHEMBL1533643 | 0.91 | TSHR (0.73) | TSHRHTR6LMNAMPOCYP3A4 | |
| Dapsone SCHEMBL27773927 | 0.85 | HTR6 (0.89) | TSHRHTR6LMNAMPOCYP3A4 | |
| Dapsone SCHEMBL2031998 | 0.85 | HTR6 (0.89) | TSHRHTR6LMNAMPOCYP3A4 | |
| Dapsone SCHEMBL21428 | 0.85 | HTR6 (1.00) | TSHRHTR6LMNAMPOCYP3A4 | |
| Dapsone SCHEMBL1219599 | 0.85 | HTR6 (1.00) | TSHRHTR6LMNAMPOCYP3A4 | |
| Dapsone SCHEMBL5055312 | 0.85 | HTR6 (1.00) | TSHRHTR6LMNAMPOCYP3A4 | |
| SCHEMBL324893 | 0.85 | HTR6 (1.00) | TSHRHTR6LMNAMPOCYP3A4 | |
| SCHEMBL10596934 | 0.85 | HTR6 (1.00) | TSHRHTR6LMNAMPOCYP3A4 | |
| Acetic Acid SCHEMBL2282444 | 0.84 | TSHR (0.78) | TSHRHTR6LMNAMPOCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118141991-A | Use of composite materials | 贺利氏医疗有限公司 | 2024-06-07 | — | — | CN | disclosed |
| CN-117897176-A | Compositions and methods for modulating tissue distribution of intracellular therapeutic agents | 恩特拉达治疗学股份有限公司 | 2024-04-16 | — | — | CN | disclosed |
| CN-113813294-A | Compositions and methods for treating liver diseases and disorders | E·麦肯纳 | 2021-12-21 | — | — | CN | disclosed |
| CN-1642503-A | Therapeutical polyanhydride compounds for drug delivery | UNIV RUTGERS (US) | 2005-07-20 | — | — | CN | disclosed |