SCHEMBL276050

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

	Compound	similarity	top predicted	shared targets
	SCHEMBL277694	0.82	MAP4K4 (0.42)	PDE3BPDE3AERN1PRKCZCYP1A2
	SCHEMBL1899820	0.76	NPC1 (0.47)	PDE3BPDE3AROCK2IMPDH2MALT1
	SCHEMBL30695314	0.73	IMPDH2 (0.42)	PDE3BPDE3AROCK2IMPDH2MALT1
	SCHEMBL3064494	0.73	IMPDH2 (0.42)	PDE3BPDE3AROCK2IMPDH2MALT1
	SCHEMBL29889874	0.73	CYP1A2 (0.52)	PDE3BPDE3ACTSAKDM4ECYP1A2
	SCHEMBL3952608	0.73	MALT1 (0.37)	PDE3BPDE3AROCK2ERN1IMPDH2
	SCHEMBL4291880	0.73	PDE3B (0.35)	PDE3BPDE3AROCK2ERN1IMPDH2
	SCHEMBL20019250	0.73	CYP1A2 (0.35)	PDE3BPDE3AROCK2ERN1IMPDH2
	SCHEMBL276051	0.73	KDM4E (0.41)	PDE3BPDE3AROCK2ERN1IMPDH2
	SCHEMBL558005	0.73	BACE1 (0.52)	IMPDH2PRKCZCYP1A2CYP3A4CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 38 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.