Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 2/20 | 0.47 |
| ▸ | P2RX3 | P56373 | 12/20 | 0.43 |
| ▸ | P2RX2 | Q9UBL9 | 12/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2760639 | 1.00 | P2RX7 (0.47) | P2RX7P2RX3P2RX2MAPTTP53 | |
| SCHEMBL2760722 | 0.91 | P2RX3 (0.49) | P2RX7P2RX3P2RX2MAPTTP53 | |
| SCHEMBL2760721 | 0.91 | P2RX3 (0.49) | P2RX7P2RX3P2RX2MAPTTP53 | |
| SCHEMBL2760883 | 0.90 | NPC1 (0.46) | P2RX3P2RX2MAPTTP53NPC1 | |
| SCHEMBL2760882 | 0.90 | NPC1 (0.46) | P2RX3P2RX2MAPTTP53NPC1 | |
| SCHEMBL2760840 | 0.90 | P2RX7 (0.45) | P2RX7P2RX3P2RX2MAPTTP53 | |
| SCHEMBL2760841 | 0.90 | P2RX7 (0.45) | P2RX7P2RX3P2RX2MAPTTP53 | |
| SCHEMBL2760834 | 0.83 | P2RX7 (0.41) | P2RX7P2RX3P2RX2 | |
| SCHEMBL2761013 | 0.81 | P2RX7 (0.47) | P2RX7P2RX3P2RX2NPC1RAB9A | |
| SCHEMBL1495682 | 0.81 | NR1I2 (0.55) | P2RX3P2RX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2262766-A2 | AMIDE COMPOUNDS, COMPOSITIONS AND USES THEREOF | Renovis, Inc. (US) | 2010-12-22 | — | — | EP | disclosed |
| WO-2009110985-A2 | AMIDE COMPOUNDS, COMPOSITIONS AND USES THEREOF | RENOVIS, INC. (US) | 2009-09-11 | — | — | WO | disclosed |