Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | AKR1C3 | P42330 | 4/20 | 0.42 |
| ▸ | AKR1C4 | P17516 | 3/20 | 0.42 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.42 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.41 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.41 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.41 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.41 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.41 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.41 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.41 |
| ▸ | EP300 | Q09472 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2760882 | 1.00 | NPC1 (0.46) | NPC1RAB9AMAPTTP53AKR1C3 | |
| SCHEMBL12757626 | 0.90 | AKR1C3 (0.50) | AKR1C3AKR1C4AKR1C2P2RX3P2RX2 | |
| SCHEMBL2760639 | 0.90 | P2RX7 (0.47) | NPC1RAB9AMAPTTP53LMNA | |
| SCHEMBL2760640 | 0.90 | P2RX7 (0.47) | NPC1RAB9AMAPTTP53LMNA | |
| SCHEMBL2760776 | 0.89 | PSEN1 (0.41) | NPC1RAB9AMAPTTP53AKR1C3 | |
| SCHEMBL2760777 | 0.89 | PSEN1 (0.41) | NPC1RAB9AMAPTTP53AKR1C3 | |
| SCHEMBL2760578 | 0.85 | PSEN1 (0.40) | NPC1RAB9AMAPTTP53PSEN1 | |
| SCHEMBL2760579 | 0.85 | PSEN1 (0.40) | NPC1RAB9AMAPTTP53PSEN1 | |
| SCHEMBL2760782 | 0.84 | NPC1 (0.49) | NPC1RAB9AMAPTTP53AKR1C3 | |
| SCHEMBL2760721 | 0.80 | P2RX3 (0.49) | NPC1RAB9AMAPTTP53LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2262766-A2 | AMIDE COMPOUNDS, COMPOSITIONS AND USES THEREOF | Renovis, Inc. (US) | 2010-12-22 | — | — | EP | disclosed |
| WO-2009110985-A2 | AMIDE COMPOUNDS, COMPOSITIONS AND USES THEREOF | RENOVIS, INC. (US) | 2009-09-11 | — | — | WO | disclosed |