Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 9/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.42 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | MPL | P40238 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4666187 | 0.80 | RAD52 (0.59) | MKNK1MKNK2NPC1RAB9AALDH1A1 | |
| SCHEMBL14843891 | 0.79 | MKNK1 (0.49) | MKNK1MKNK2KDRMPL | |
| SCHEMBL4988484 | 0.77 | MKNK1 (0.39) | MKNK1MKNK2CCNA2CDK2CCNA1 | |
| SCHEMBL2793375 | 0.77 | NPC1 (0.54) | NFKB1NPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL30611577 | 0.77 | MEN1 (0.56) | MKNK1MKNK2NPC1RAB9AALDH1A1 | |
| SCHEMBL29134221 | 0.77 | NFKB1 (0.58) | NFKB1NPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL23867504 | 0.76 | RAB9A (0.46) | MKNK1MKNK2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL10033201 | 0.76 | MKNK1 (0.44) | MKNK1MKNK2KDRMPL | |
| SCHEMBL30062475 | 0.76 | MEN1 (0.67) | NPC1RAB9ASMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL2789615 | 0.76 | RAB9A (0.64) | NFKB1NPC1RAB9ASMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1625400-A | 2, 4-pyrimidinediamine compounds and uses thereof | RIGEL PHARMACEUTICALS INC (US) | 2005-06-08 | — | — | CN | disclosed |