Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.31 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27492595 | 0.78 | PGR (0.50) | MEN1ALDH1A1GAAMAPTHPGD | |
| SCHEMBL27475516 | 0.76 | PDE3B (0.43) | PDPK1 | |
| SCHEMBL27475517 | 0.75 | DYRK1A (0.34) | — | |
| SCHEMBL27475514 | 0.74 | PGR (0.32) | ALDH1A1GAAMAPTHPGD | |
| SCHEMBL27491886 | 0.73 | PGR (0.58) | — | |
| SCHEMBL27288473 | 0.73 | PPARA (0.36) | MEN1ALDH1A1GAAMAPTHPGD | |
| SCHEMBL27491175 | 0.72 | PGR (0.46) | MEN1ALDH1A1MAPTRECQLKMT2A | |
| SCHEMBL27473389 | 0.72 | TDP2 (0.43) | — | |
| SCHEMBL27495546 | 0.71 | — | — | |
| SCHEMBL27475515 | 0.71 | LMNA (0.38) | MEN1GAAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100360505-C | Quinazoline derivatives as angiogenesis inhibitors | ASTRAZENECA AB (SE) | 2008-01-09 | — | — | CN | disclosed |
| CN-1597667-A | Quinazoline derivatives as angiogenesis inhibitors | ASTRAZENECA AB (SE) | 2005-03-23 | — | — | CN | disclosed |