Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.43 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27612384 | 0.89 | LMNA (0.44) | ALDH1A1TSHRLMNAMAPTL3MBTL1 | |
| SCHEMBL5798751 | 0.84 | NOTUM (0.62) | LMNAMAPTNOTUMKDM4EGAA | |
| SCHEMBL29923052 | 0.79 | NOTUM (0.69) | ALDH1A1TSHRLMNAMAPTL3MBTL1 | |
| SCHEMBL20059520 | 0.79 | NOTUM (0.69) | ALDH1A1TSHRLMNAMAPTL3MBTL1 | |
| SCHEMBL7416927 | 0.72 | NOTUM (0.62) | LMNAMAPTNOTUMKDM4EGAA | |
| SCHEMBL3035084 | 0.72 | NOTUM (0.46) | ALDH1A1NOTUMGAASMN1; SMN2SLC22A12 | |
| SCHEMBL4611468 | 0.72 | MAPT (0.41) | ALDH1A1LMNAMAPTNOTUMKDM4E | |
| SCHEMBL6747225 | 0.71 | NOTUM (0.43) | ALDH1A1TSHRLMNAMAPTL3MBTL1 | |
| SCHEMBL29963540 | 0.71 | BRD4 (0.51) | ALDH1A1LMNAMAPTL3MBTL1NOTUM | |
| SCHEMBL2306434 | 0.71 | BRD4 (0.51) | ALDH1A1LMNAMAPTL3MBTL1NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1678321-A | Methods of treating or preventing autoimmune diseases with 2, 4-pyrimidinediamine compounds | RIGEL PHARMACEUTICALS INC (US) | 2005-10-05 | — | — | CN | disclosed |