Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.62 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | PKLR | P30613 | 1/20 | 0.42 |
| ▸ | TNF | P01375 | 4/20 | 0.41 |
| ▸ | NOD2 | Q9HC29 | 4/20 | 0.41 |
| ▸ | NOD1 | Q9Y239 | 4/20 | 0.41 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7416927 | 0.88 | NOTUM (0.62) | NOTUMHSD17B3KDM4EMAPTMEN1 | |
| SCHEMBL27612686 | 0.84 | ALDH1A1 (0.43) | NOTUMKDM4EMAPTGAASLC22A12 | |
| SCHEMBL32673839 | 0.80 | NOTUM (0.56) | NOTUMMAPTPKLRTNFNOD2 | |
| SCHEMBL2586534 | 0.77 | NOTUM (1.00) | NOTUMMAPTMEN1KMT2ASLC22A12 | |
| SCHEMBL10167044 | 0.77 | NOTUM (1.00) | NOTUMMAPTMEN1KMT2ASLC22A12 | |
| SCHEMBL5523654 | 0.77 | NOTUM (1.00) | NOTUMMAPTMEN1KMT2ASLC22A12 | |
| SCHEMBL8169775 | 0.77 | NOTUM (0.56) | NOTUMKMT2APKLRTNFNOD2 | |
| SCHEMBL29737224 | 0.77 | NOTUM (0.56) | NOTUMKMT2APKLRTNFNOD2 | |
| SCHEMBL5798736 | 0.77 | MAPT (0.67) | NOTUMKDM4EMAPTGAATNF | |
| SCHEMBL3035084 | 0.75 | NOTUM (0.46) | NOTUMGAAPKLRTNFNOD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006058338-A2 | 4 - PIPERIDINECARBOXAMIDE DERIVATIVES AS MODULATORS OF VANILLOID VR1 RECEPTOR | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-06-01 | — | — | WO | disclosed |
| US-20060116368-A1 | 4-Piperidinecarboxamide modulators of vanilloid VR1 receptor | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-06-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060116368-A1 | 4-Piperidinecarboxamide modulators of vanilloid VR1 receptor | VDAC1, TRPV1, HVCN1 | NOTUM 3548/4885HSD17B3 4207/4885KDM4E 2664/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.