Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | DHFR | P00374 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4408689 | 0.89 | MAPT (0.45) | LMNAALDH1A1KDM4EMAPTSMN1; SMN2 | |
| SCHEMBL27631912 | 0.84 | PIK3CG (0.44) | TSHRCASP1MAPTSMN1; SMN2HPGD | |
| SCHEMBL27612799 | 0.83 | MAP4K4 (0.43) | CYP1A1LMNAMAPTRAB9ASMN1; SMN2 | |
| SCHEMBL27613037 | 0.81 | PIK3CG (0.44) | NPC1ADORA2AADORA1 | |
| SCHEMBL27631713 | 0.80 | ADORA2A (0.51) | LMNAALDH1A1KDM4EMAPTSMN1; SMN2 | |
| SCHEMBL27612435 | 0.79 | ALDH1A1 (0.48) | TSHRALDH1A1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL27631649 | 0.78 | POLB (0.45) | TSHRCASP1ALDH1A1KDM4EMAPT | |
| SCHEMBL4411196 | 0.77 | RAB9A (0.56) | ALDH1A1RAB9AKMT2AMEN1ADORA2A | |
| SCHEMBL27631564 | 0.76 | DHFR (0.52) | TSHRALDH1A1KDM4EDHFRKMT2A | |
| SCHEMBL4463336 | 0.76 | HEXA (0.47) | TSHRALDH1A1RAB9ADHFRADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1678321-A | Methods of treating or preventing autoimmune diseases with 2, 4-pyrimidinediamine compounds | RIGEL PHARMACEUTICALS INC (US) | 2005-10-05 | — | — | CN | disclosed |