Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 4/20 | 0.58 |
| ▸ | MKNK2 | Q9HBH9 | 4/20 | 0.58 |
| ▸ | CYP2A6 | P11509 | 3/20 | 0.54 |
| ▸ | WNT3A | P56704 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 2/20 | 0.45 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.45 |
| ▸ | ABL1 | P00519 | 1/20 | 0.45 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.45 |
| ▸ | LCK | P06239 | 1/20 | 0.45 |
| ▸ | FYN | P06241 | 1/20 | 0.45 |
| ▸ | CSF1R | P07333 | 1/20 | 0.45 |
| ▸ | RET | P07949 | 1/20 | 0.45 |
| ▸ | IGF1R | P08069 | 1/20 | 0.45 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.45 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.45 |
| ▸ | FLT1 | P17948 | 1/20 | 0.45 |
| ▸ | LTK | P29376 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27612999 | 0.82 | CYP17A1 (0.42) | WNT3ACYP3A4LMNAKIF11CYP11B2 | |
| SCHEMBL27594282 | 0.76 | DYRK1A (0.51) | MKNK1MKNK2CYP2A6CYP3A4ALDH1A1 | |
| SCHEMBL31338446 | 0.76 | LMNA (0.67) | MKNK1MKNK2CYP2A6WNT3ACYP3A4 | |
| SCHEMBL2385420 | 0.76 | LMNA (0.67) | MKNK1MKNK2CYP2A6WNT3ACYP3A4 | |
| SCHEMBL27594249 | 0.76 | ADRB2 (0.50) | CYP2A6WNT3ACLK4LMNA | |
| SCHEMBL12251218 | 0.75 | MKNK1 (0.58) | MKNK1MKNK2CYP2A6WNT3ACYP3A4 | |
| SCHEMBL27612848 | 0.75 | CYP2A6 (0.61) | MKNK1MKNK2CYP2A6CYP3A4ALDH1A1 | |
| SCHEMBL30462079 | 0.74 | MKNK1 (1.00) | MKNK1MKNK2CYP2A6WNT3ACYP3A4 | |
| SCHEMBL6212482 | 0.74 | MKNK1 (1.00) | MKNK1MKNK2CYP2A6WNT3ACYP3A4 | |
| SCHEMBL8807174 | 0.74 | CYP2A6 (0.67) | MKNK1MKNK2CYP2A6CYP3A4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1585775-A | 6-O-acyl ketolide derivatives of erythromycine useful as antibacterials | ORTHO MCNEIL PHARM INC (US) | 2005-02-23 | — | — | CN | disclosed |