Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.54 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.53 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.53 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 5/20 | 0.49 |
| ▸ | PKM | P14618 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 3/20 | 0.47 |
| ▸ | FLT1 | P17948 | 1/20 | 0.46 |
| ▸ | FLT4 | P35916 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27563637 | 0.90 | GAA (0.52) | NR1H4KMT2AMEN1MAPK1GAA | |
| SCHEMBL27462168 | 0.85 | ADRB2 (0.52) | NR1H4TDP1KMT2AADRB2ADRB1 | |
| SCHEMBL27615400 | 0.84 | NR1H4 (0.39) | NR1H4TDP1KMT2AADRB2ADRB1 | |
| SCHEMBL27552998 | 0.84 | ALDH1A1 (0.41) | NR1H4TDP1KMT2AADRB2ADRB1 | |
| SCHEMBL27615288 | 0.81 | ALDH1A1 (0.39) | NR1H4TDP1KMT2AADRB2ADRB1 | |
| SCHEMBL751610 | 0.81 | NR1H4 (0.59) | NR1H4TDP1KMT2AADRB2ADRB1 | |
| SCHEMBL27696889 | 0.81 | FLT1 (0.47) | MAPK1MAPTPOLBFLT1FLT4 | |
| SCHEMBL27731315 | 0.80 | NR1H4 (0.58) | NR1H4TDP1KMT2AADRB2ADRB1 | |
| SCHEMBL14850043 | 0.79 | KMT2A (0.64) | NR1H4TDP1KMT2AADRB2ADRB1 | |
| SCHEMBL222270 | 0.79 | TDP1 (0.67) | NR1H4TDP1KMT2AADRB2ADRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100343238-C | Quinazoline derivatives as antitumor agents | ASTRAZENECA AB (SE) | 2007-10-17 | — | — | CN | disclosed |
| CN-1585754-A | Quinazoline derivatives as antitumor agents | ASTRAZENECA AB (SE) | 2005-02-23 | — | — | CN | disclosed |