SCHEMBL2761544

SCHEMBL2761544

O=c1cc(O)c2cc(Br)ccc2o1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PIM1 P11309 1/20 1.00
CA12 O43570 3/20 0.59
CA9 Q16790 3/20 0.59
CA1 P00915 1/20 0.59
ALDH1A1 P00352 2/20 0.53
KMT2A Q03164 2/20 0.53
KDM4E B2RXH2 1/20 0.53
GABRP O00591 4/20 0.47
GABRD O14764 4/20 0.47
GABRA1 P14867 4/20 0.47
GABRB1 P18505 4/20 0.47
GABRG2 P18507 4/20 0.47
GABRB3 P28472 4/20 0.47
GABRA5 P31644 4/20 0.47
GABRA3 P34903 4/20 0.47
GABRA2 P47869 4/20 0.47
GABRB2 P47870 4/20 0.47
GABRA4 P48169 4/20 0.47
GABRE P78334 4/20 0.47
GABRA6 Q16445 4/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3524488 0.85 PIM1 (0.74) PIM1CA12CA9CA1ALDH1A1
SCHEMBL31290723 0.85 PIM1 (0.74) PIM1CA12CA9CA1ALDH1A1
SCHEMBL5341818 0.81 KDM4E (0.72) PIM1CA12CA9CA1ALDH1A1
SCHEMBL11828800 0.79 PIM1 (0.66) PIM1CA12CA9KDM4EGABRP
SCHEMBL23640512 0.78 PIM1 (0.64) PIM1CA12CA9CA1ALDH1A1
SCHEMBL5336545 0.78 PIM1 (0.64) PIM1CA12CA9CA1ALDH1A1
SCHEMBL19501076 0.78 PIM1 (0.64) PIM1CA12CA9CA1ALDH1A1
SCHEMBL2492142 0.78 PIM1 (0.64) PIM1CA12CA9CA1ALDH1A1
SCHEMBL2490464 0.78 PIM1 (0.64) PIM1CA12CA9CA1ALDH1A1
SCHEMBL3539546 0.78 PIM1 (0.64) PIM1CA12CA9CA1GABRP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 73 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114426587-A Modified cassia seed polysaccharide and preparation method and application thereof 河北科技大学 2022-05-03 CN claimed
CN-112517060-B Catalyst, application and synthesis method of 4-hydroxycoumarin derivative 山东农业大学 2022-03-25 CN claimed
CN-110386998-B Coumarin inulin derivative and preparation and application thereof 中国科学院烟台海岸带研究所 2021-08-06 CN claimed
CN-112517060-A Catalyst, application and synthesis method of 4-hydroxycoumarin derivative 山东农业大学 2021-03-19 CN claimed
CN-104387405-B Method for synthesizing furo [3,2-c ] coumarin derivative 长沙理工大学 2016-06-15 CN claimed
CN-105646517-A Preparation methods of natural product Hirtellanine B and derivatives thereof and application of natural product Hirtellanine B and derivatives thereof in preparation of drug for treating tumor 巴塞利亚药业(中国)有限公司 2016-06-08 CN claimed
CN-102846598-A Application of coumarin in preparing formation inhibitors of advanced glycation end products (AGEs) GUANGZHOU KANGCHENG PHARMACEUTICAL RES CO LTD 2013-01-02 CN claimed
WO-2012135493-A1 POLYMERS AND TASK FUNCTIONALIZED POLYMERS FOR ENHANCED CHANGE DETECTION ENVIRONMENTAL TECHNOLOGY SOLUTIONS (US) 2012-10-04 WO claimed
US-20250074925-A1 RARE EARTH COMPLEX SAGAMI CHEMICAL RESEARCH INSTITUTE (JP) 2025-03-06 US disclosed
CN-119192119-A Coumarin thioether pleuromutilin derivative and application thereof 西华大学 2024-12-27 CN disclosed
CN-118834490-A Photo-crosslinkable perfluorinated ion membrane and preparation method thereof 上海交通大学 2024-10-25 CN disclosed
EP-4365180-A1 RARE EARTH COMPLEX Tosoh Corporation (JP) 2024-05-08 EP disclosed
CN-117616032-A Rare earth complex 东曹株式会社 2024-02-27 CN disclosed
CN-117069063-A Sodium hydride suspension and application thereof in flow chemical reaction 武汉药明康德新药开发有限公司 2023-11-17 CN disclosed
US-5106407-A Algicides, funcilides, bactericides THE DOW CHEMICAL COMPANY (US) 1992-04-21 US disclosed
US-4097475-A FOR POLYESTERS AND BLENDS WITH CELLULOSE E. I. DU PONT DE NEMOURS AND COMPANY (US) 1978-06-27 US disclosed
US-3993670-A OPTICAL BRIGHTENERS BAYER AKTIENGESELLSCHAFT (DT) 1976-11-23 US disclosed
US-3974289-A Coumarin derivatives for the treatment of allergies BEECHAM GROUP LIMITED (EN) 1976-08-10 US disclosed
US-3971731-A OPTICAL BRIGHTENER, UV ABSORBER BAYER AKTIENGESELLSCHAFT (DT) 1976-07-27 US disclosed
US-3968119-A OPTICAL BRIGHTENERS BAYER AKTIENGESELLSCHAFT (DT) 1976-07-06 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250074925-A1 RARE EARTH COMPLEX L1CAM, CHRM1, NPM1 PIM1 2767/4885CA12 669/4885CA9 1421/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.