Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 known ✓ | Q99720 | 2/20 | 0.59 |
| ▸ | SLC6A2 known ✓ | P23975 | 3/20 | 0.48 |
| ▸ | HTR1A known ✓ | P08908 | 1/20 | 0.48 |
| ▸ | ADRA2A known ✓ | P08913 | 1/20 | 0.48 |
| ▸ | HTR3A known ✓ | P46098 | 1/20 | 0.48 |
| ▸ | SLC6A4 known ✓ | P31645 | 2/20 | 0.47 |
| ▸ | ADRB3 known ✓ | P13945 | 1/20 | 0.47 |
| ▸ | ADRB2 known ✓ | P07550 | 2/20 | 0.44 |
| ▸ | ADRB1 known ✓ | P08588 | 1/20 | 0.44 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.44 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.44 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.59 |
| ▸ | ESR1 | P03372 | 1/20 | 0.56 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.56 |
| ▸ | BLM | P54132 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | F13A1 | P00488 | 1/20 | 0.52 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8576229 | 0.98 | TMEM97 (0.61) | TMEM97SIGMAR1ESR1ESR2BLM | |
| Bromide SCHEMBL27562319 | 0.98 | TMEM97 (0.61) | TMEM97SIGMAR1ESR1ESR2BLM | |
| SCHEMBL1091362 | 0.95 | TMEM97 (0.64) | TMEM97SIGMAR1ESR1ESR2BLM | |
| SCHEMBL7381628 | 0.78 | TMEM97 (0.67) | TMEM97SIGMAR1ESR1ESR2BLM | |
| Dopamine SCHEMBL1809112 | 0.78 | KDM4E (0.67) | SIGMAR1BLMKMT2ATDP1KDM4E | |
| Bromide SCHEMBL6337077 | 0.77 | TMEM97 (0.95) | TMEM97SIGMAR1ESR1ESR2BLM | |
| Bromide SCHEMBL10589642 | 0.77 | TMEM97 (0.59) | TMEM97SIGMAR1ESR1ESR2BLM | |
| Hydrochloric Acid SCHEMBL5115776 | 0.77 | TMEM97 (0.95) | TMEM97SIGMAR1ESR1ESR2BLM | |
| Bromide SCHEMBL29131748 | 0.76 | LMNA (0.56) | SIGMAR1BLMTDP1KDM4ECA2 | |
| Hydrochloric Acid SCHEMBL8893728 | 0.76 | GAA (0.58) | SIGMAR1BLMKMT2ATDP1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108700541-A | Electrochemical sensor and painting method, manufacturing method and corresponding purposes | 加泰罗尼亚理工大学 | 2018-10-23 | — | — | CN | disclosed |
| CN-101636379-A | Amine derivatives and their use in beta-2-adrenoreceptor mediated diseases | ASTRAZENECA AB | 2010-01-27 | — | — | CN | disclosed |
| CN-1720224-A | Vascular balancing agents and methods of use thereof | TARGEGEN INC (US) | 2006-01-11 | — | — | CN | disclosed |