Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | KDM6B | O15054 | 1/20 | 0.40 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 5/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | PDK1 | Q15118 | 2/20 | 0.35 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.35 |
| ▸ | PDK3 | Q15120 | 2/20 | 0.35 |
| ▸ | PDK4 | Q16654 | 2/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5562128 | 0.82 | AAK1 (0.44) | MEN1TSHRKMT2AKDM4EPDK1 | |
| SCHEMBL27615897 | 0.80 | AR (0.42) | MEN1TSHRKMT2AKDM6BKDM4C | |
| SCHEMBL27615843 | 0.79 | MAPT (0.44) | MEN1TSHRKMT2ALMNAALDH1A1 | |
| SCHEMBL6608117 | 0.76 | PTGER4 (0.47) | KDM4EKDM4CHDAC1NPC1RAB9A | |
| SCHEMBL1726529 | 0.75 | PRKCI (0.41) | MEN1KMT2AKDM4EHPGDHDAC1 | |
| SCHEMBL27597105 | 0.75 | CD44 (0.52) | MEN1KMT2AKDM4EHPGDHDAC1 | |
| SCHEMBL27597109 | 0.74 | PTGS2 (0.44) | MEN1TSHRKMT2AKDM4ELMNA | |
| SCHEMBL27597171 | 0.72 | CD44 (0.52) | MEN1KMT2AKDM4EHPGDHDAC1 | |
| SCHEMBL27597110 | 0.71 | ALDH1A1 (0.33) | MEN1KMT2AKDM4EHDAC1ALDH1A1 | |
| SCHEMBL27539460 | 0.70 | TSHR (0.38) | MEN1TSHRKMT2AKDM4EKDM6B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100497333-C | Dihydrobenzodiazepin-2-one derivatives for the treatment of neurological disorders | HOFFMANN LA ROCHE (CH) | 2009-06-10 | — | — | CN | disclosed |
| CN-1633430-A | Dihydrobenzodiazepin-2-one derivatives for the treatment of neurological disorders | HOFFMANN LA ROCHE (CH) | 2005-06-29 | — | — | CN | disclosed |