Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA4 | P22748 | 5/20 | 0.90 |
| ▸ | FAHD1 | Q6P587 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.31 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.31 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | LDHA | P00338 | 1/20 | 0.30 |
| ▸ | BLM | P54132 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL8761101 | 1.00 | CA4 (0.90) | CA4FAHD1CASP1FFAR3HDAC3 | |
| Citric Acid SCHEMBL28869337 | 0.97 | CA4 (0.85) | CA4FAHD1CASP1 | |
| Citric Acid SCHEMBL989893 | 0.97 | CA4 (0.94) | CA4FAHD1CASP1FFAR3HDAC3 | |
| Citric Acid SCHEMBL6687136 | 0.97 | CA4 (0.94) | CA4FAHD1CASP1FFAR3HDAC3 | |
| Citric Acid SCHEMBL2307826 | 0.97 | CA4 (0.94) | CA4FAHD1CASP1FFAR3HDAC3 | |
| Citric Acid SCHEMBL9364269 | 0.97 | CA4 (0.84) | CA4FAHD1CASP1ALDH1A1 | |
| Citric Acid SCHEMBL6690080 | 0.97 | CA4 (0.94) | CA4FAHD1CASP1FFAR3HDAC3 | |
| Citric Acid SCHEMBL5982475 | 0.97 | CA4 (0.84) | CA4FAHD1CASP1ALDH1A1 | |
| Citric Acid SCHEMBL23672268 | 0.95 | CA4 (0.90) | CA4FAHD1CASP1FFAR3HDAC3 | |
| Citric Acid SCHEMBL5617376 | 0.95 | CA4 (0.90) | CA4FAHD1CASP1FFAR3HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1699634-A | Method for electroplating magnesium and magnesium alloy | UNIV SHENYANG TECHNOLOGY (CN) | 2005-11-23 | — | — | CN | disclosed |