Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE2 | Q9BYF1 | 3/20 | 0.58 |
| ▸ | PREP | P48147 | 3/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | KLK7 | P49862 | 1/20 | 0.52 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5269200 | 1.00 | ACE2 (0.58) | ACE2PREPSMN1; SMN2NPC1RAB9A | |
| SCHEMBL3049973 | 0.84 | PREP (0.58) | ACE2PREPSMN1; SMN2NPC1RAB9A | |
| SCHEMBL15372095 | 0.83 | PREP (0.59) | ACE2PREPSMN1; SMN2NPC1RAB9A | |
| SCHEMBL1355639 | 0.83 | PREP (0.59) | ACE2PREPSMN1; SMN2NPC1RAB9A | |
| SCHEMBL475715 | 0.83 | PREP (0.67) | PREPSMN1; SMN2CTRB1HSD17B10NPSR1 | |
| SCHEMBL812253 | 0.83 | PREP (0.57) | ACE2PREPSMN1; SMN2NPC1RAB9A | |
| SCHEMBL13769204 | 0.83 | PREP (0.57) | ACE2PREPSMN1; SMN2NPC1RAB9A | |
| SCHEMBL29553 | 0.83 | PREP (0.67) | PREPSMN1; SMN2CTRB1HSD17B10NPSR1 | |
| SCHEMBL205223 | 0.83 | PREP (0.67) | PREPSMN1; SMN2CTRB1HSD17B10NPSR1 | |
| SCHEMBL7419110 | 0.83 | PREP (0.57) | ACE2PREPSMN1; SMN2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102219750-B | N-substituted hydroxypyrimidinone carboxamide inhibitors of HIV integrase | ANGELETTI P IST RICHERCHE BIO | 2013-05-29 | — | — | CN | disclosed |
| CN-102229605-A | N-substituted hydroxypyrimidinone carboxamide inhibitors of HIV integrase | ANGELETTI P IST RICHERCHE BIO | 2011-11-02 | — | — | CN | disclosed |
| CN-102219750-A | N-substituted hydroxypyrimidinone carboxamide inhibitors of HIV integrase | ANGELETTI P IST RICHERCHE BIO | 2011-10-19 | — | — | CN | disclosed |
| CN-1700918-B | N-substituted hydroxypyrimidinone carboxamide inhibitors of HIV integrase | ANGELETTI P IST RICHERCHE BIO | 2011-06-08 | — | — | CN | disclosed |
| CN-1960990-A | Cyclohexylalanine derivatives as dipeptidyl peptidase-IV inhibitors for the treatment or prevention of diabetes | MERCK & CO INC (US) | 2007-05-09 | — | — | CN | disclosed |
| CN-1700918-A | N-substituted hydroxypyrimidinone carboxamide inhibitors of HIV integrase | ANGELETTI P IST RICHERCHE BIO (IT) | 2005-11-23 | — | — | CN | disclosed |
| CN-1688527-A | Fused benzene derivatives and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2005-10-26 | — | — | CN | disclosed |