Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 5/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | CACNA2D1 | P54289 | 7/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 3/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.37 |
| ▸ | USP14 | P54578 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.36 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.36 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6895665 | 0.83 | LMNA (0.34) | ALDH1A1KDM4EHSD17B10TSHRGAA | |
| SCHEMBL1625943 | 0.81 | PTGER4 (0.38) | HPGDALDH1A1KDM4EHSD17B10TSHR | |
| SCHEMBL1627487 | 0.81 | PTGER4 (0.36) | ALDH1A1KDM4ETSHRGAAUSP14 | |
| SCHEMBL1625557 | 0.81 | PTGER4 (0.36) | ALDH1A1KDM4EHSD17B10USP2TSHR | |
| SCHEMBL27582799 | 0.78 | PTGER4 (0.36) | ALDH1A1KDM4EGAAUSP14KMT2A | |
| SCHEMBL1625661 | 0.77 | USP14 (0.41) | HPGDALDH1A1KDM4EHSD17B10TSHR | |
| SCHEMBL27618314 | 0.77 | RXFP1 (0.43) | HPGDALDH1A1CACNA2D1RXFP1GAA | |
| SCHEMBL7192338 | 0.76 | RXRA (0.47) | HSD17B10USP14MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL27599858 | 0.72 | CYP1A2 (0.40) | HPGDALDH1A1USP2TSHRCACNA2D1 | |
| SCHEMBL27878094 | 0.67 | CACNA2D1 (0.46) | HPGDALDH1A1KDM4EHSD17B10CACNA2D1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100579518-C | Use of EP4 receptor ligands for the manufacture of a medicament for the treatment of IL-6 related disorders | PFIZER | 2010-01-13 | — | — | CN | disclosed |
| CN-101023946-A | Use of EP4 receptor ligands in the treatment of IL-6 involved diseases | PFIZER (US) | 2007-08-29 | — | — | CN | disclosed |
| CN-1658847-A | Use of EP4 receptor ligands for the treatment of IL-6 related disorders | PFIZER (US) | 2005-08-24 | — | — | CN | disclosed |