Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Quinoline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | PDE10A | Q9Y233 | 4/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | CASP1 | P29466 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | CASP7 | P55210 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Quinoline SCHEMBL27619364 | 0.99 | ALDH1A1 (0.49) | ALDH1A1PDE10ATSHRCASP1HSD17B10 | |
| Iodide SCHEMBL17092835 | 0.82 | MAOA (0.43) | ALDH1A1KDM4ESMN1; SMN2HPGDKDM1A | |
| Quinoline SCHEMBL27519483 | 0.81 | ALDH1A1 (0.45) | ALDH1A1PDE10ATSHRCASP1HSD17B10 | |
| Quinoline SCHEMBL28758483 | 0.81 | ALDH1A1 (0.45) | ALDH1A1PDE10ATSHRCASP1HSD17B10 | |
| Iodide SCHEMBL28378810 | 0.80 | MAOA (0.42) | ALDH1A1KDM4ESMN1; SMN2HPGDKDM1A | |
| SCHEMBL347425 | 0.80 | MAOA (0.45) | ALDH1A1TSHRKDM4ETP53SMN1; SMN2 | |
| SCHEMBL16728889 | 0.80 | MAOA (0.45) | ALDH1A1TSHRKDM4ETP53SMN1; SMN2 | |
| SCHEMBL29814962 | 0.80 | MAOA (0.45) | ALDH1A1TSHRKDM4ETP53SMN1; SMN2 | |
| SCHEMBL11684678 | 0.71 | MAPT (0.41) | ALDH1A1MAPTSMN1; SMN2HPGDL3MBTL1 | |
| Sulfuric Acid SCHEMBL28551070 | 0.71 | BCHE (0.39) | ALDH1A1SMN1; SMN2POLBMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1882307-A | Method for dyeing fibres containing keratine | HENKEL KGAA (DE) | 2006-12-20 | — | — | CN | disclosed |
| CN-1761517-A | Mixing device | HENKEL KGAA (DE) | 2006-04-19 | — | — | CN | disclosed |