Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 9/20 | 0.51 |
| ▸ | DRD4 | P21917 | 9/20 | 0.51 |
| ▸ | DRD3 | P35462 | 9/20 | 0.51 |
| ▸ | CHRM1 | P11229 | 7/20 | 0.51 |
| ▸ | CHRM2 | P08172 | 6/20 | 0.51 |
| ▸ | CHRM4 | P08173 | 6/20 | 0.51 |
| ▸ | CHRM5 | P08912 | 6/20 | 0.51 |
| ▸ | CHRM3 | P20309 | 6/20 | 0.51 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.51 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.51 |
| ▸ | NOS3 | P29474 | 1/20 | 0.48 |
| ▸ | NOS1 | P29475 | 1/20 | 0.48 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.46 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.46 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.46 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5537272 | 0.84 | DRD2 (0.52) | DRD2DRD4DRD3CHRM1CHRM2 | |
| SCHEMBL5542111 | 0.83 | DRD2 (0.53) | DRD2DRD4DRD3CHRM1CHRM2 | |
| SCHEMBL1763836 | 0.82 | GRIN1 (0.51) | DRD2DRD4DRD3CHRM1CHRM2 | |
| SCHEMBL5544599 | 0.81 | DRD2 (0.58) | DRD2DRD4DRD3CHRM1CHRM2 | |
| SCHEMBL2676270 | 0.81 | ATAD2 (0.59) | DRD2DRD4DRD3CHRM1CHRM2 | |
| SCHEMBL27619326 | 0.81 | CHRM1 (0.53) | DRD2DRD4DRD3CHRM1CHRM2 | |
| SCHEMBL4100824 | 0.80 | GRIN1 (0.49) | DRD2DRD4DRD3CHRM1CHRM2 | |
| SCHEMBL2676091 | 0.80 | ATAD2 (0.60) | DRD2DRD4DRD3CHRM1CHRM2 | |
| SCHEMBL4103777 | 0.78 | CHRM1 (0.75) | DRD2DRD4DRD3CHRM1CHRM2 | |
| SCHEMBL5539818 | 0.78 | ATAD2 (0.54) | DRD2DRD4DRD3CHRM1CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1635891-A | Tetrahydroquinoline analogues as muscarinic agonists | ACADIA PHARM INC (US) | 2005-07-06 | — | — | CN | claimed |
| CN-1635891-A | Tetrahydroquinoline analogues as muscarinic agonists | ACADIA PHARM INC (US) | 2005-07-06 | — | — | CN | disclosed |