SCHEMBL27619342

SCHEMBL27619342

CC(C)S(=O)(=O)N(C)C(=O)c1cc(N)c(F)cc1Cl

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2C19 P33261 1/20 0.36
SCN9A Q15858 1/20 0.33
HPGD P15428 2/20 0.33
LMNA P02545 1/20 0.33
MAPT P10636 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
POLB P06746 1/20 0.33
APEX1 P27695 1/20 0.33
ALDH1A1 P00352 3/20 0.32
KDM4E B2RXH2 1/20 0.32
GAA P10253 1/20 0.32
NPSR1 Q6W5P4 1/20 0.32
CA12 O43570 2/20 0.31
CA1 P00915 2/20 0.31
CA2 P00918 2/20 0.31
CA3 P07451 2/20 0.31
CA4 P22748 2/20 0.31
CA6 P23280 2/20 0.31
CA5A P35218 2/20 0.31
CA7 P43166 2/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9877761 0.74 PIK3CA (0.37) CYP2C19HPGDLMNAMAPTSMN1; SMN2
SCHEMBL24722332 0.74 MEN1 (0.35) CYP2C19SCN9AHPGDLMNAMAPT
SCHEMBL713577 0.74 SCN9A (0.46) CYP2C19SCN9APOLBAPEX1
SCHEMBL9878081 0.73 HSP90AA1 (0.42) MAPTSMN1; SMN2POLBAPEX1ALDH1A1
SCHEMBL26563572 0.71 POLB (0.40) CYP2C19HPGDLMNAMAPTSMN1; SMN2
SCHEMBL8879615 0.71 POLB (0.42) CYP2C19HPGDLMNAMAPTSMN1; SMN2
SCHEMBL9879189 0.70 SMN1; SMN2 (0.51) HPGDLMNAMAPTSMN1; SMN2POLB
SCHEMBL6740081 0.70 LMNA (0.45) CYP2C19HPGDLMNAMAPTSMN1; SMN2
SCHEMBL9878198 0.69 CA12 (0.46) HPGDLMNAMAPTSMN1; SMN2POLB
SCHEMBL1786163 0.69 CA12 (0.46) HPGDMAPTSMN1; SMN2POLBAPEX1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-100368392-C Bifunctional phenyliso(thio)cyanates, processes and intermediates products for their preparation BASF AG (DE) 2008-02-13 CN disclosed
CN-1717388-A Bifunctional phenyliso(thio)cyanates, processes and intermediates products for their preparation BASF AG (DE) 2006-01-04 CN disclosed